Benzodiazepines and GHB: Detection and Pharmacology by Salvatore J. SalamoneBenzodiazepines and GHB: Detection and Pharmacology by Salvatore J. Salamone

Benzodiazepines and GHB: Detection and Pharmacology

EditorSalvatore J. Salamone

Paperback | November 19, 2010

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Prominent experts explain the pharmacology and metabolism of benzodiazepines (LDB) and g-hydroxybutyric acid (GHB) and offer powerful and effective methodologies that will enable better detection of these drugs in various body fluids, as well as in hair. The techniques include highly sensitive immunoassay detection of LDBs, the detection of Rohypnol® and other LDBs by mass spectrometry, and the ultrasensitive detection of GHB. State-of-the-art and highly practical, Benzodiazepines and GHB: Detection and Pharmacology offers toxicologists, forensic scientists, and clinical chemists today's most effective methods for detecting these widely abused drugs that are sometimes found associated with criminal acts.
Title:Benzodiazepines and GHB: Detection and PharmacologyFormat:PaperbackDimensions:159 pages, 9.02 × 5.98 × 0.07 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617372870

ISBN - 13:9781617372872

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Table of Contents

Chapter 1Pharmacology of Flunitrazepam and Other BenzodiazepinesRudolf Brenneisen and Lionel P. RaymonIntroductionChemistryPharmacokineticsAbsorption, Distribution, and Plasma LevelsHalf-Life vs Duration of ActionMetabolism and ExcretionPharmacodynamicsSites of ActionAcute EffectChronic Administration and Abuse LiabilityPharmacokinetics vs PharmacodynamicsRohypnol®: The Debate. ReferencesChapter 2Immunoassay Detection of BenzodiazepinesTamara N. St. Claire and Salvatore J. SalamoneIntroductionOptimal Enzyme ActivityConditionsActivityCutoffImmunoassaysMethodsManual b-Glucuronidase TreatmentAutomated b-Glucuronidase Treatment.5.2.1Online with the Hitachi 7175.2.2Online with the COBAS INTEGRA 7005.2.3A General SchemeConclusionReferencesChapter 3Analysis of Flunitrazepam and Its Metabolites in Biological SpecimensMahmoud A. ElSohly and Shixia FengIntroductionMethods of AnalysisScreening MethodsHPLC AnalysisInternal StandardsExtractionHPLC ConditionsDetectionGC/MS MethodsConclusionReferencesChapter 4Analysis of Selected Low-Dose Benzodiazepines by Mass SpectrometryDennis J. Crouch and Matthew H. SlawsonIntroductionAlprazolamBackgroundMethod 1ExtractionGC/MS ConditionsMethod PerformanceMethod 2ExtractionHPLC/MS/MS ConditionsMethod PerformanceMidazolamBackgroundMethod 1ExtractionGC/MS ConditionsMethod PerformanceMethod 2ExtractionHPLC/MS ConditionsMethod PerformanceMethod 3ExtractionHPLC/MS ConditionsMethod PerformanceAdditional TechniquesLorazepamBackgroundMethod. ExtractionGC/MS ConditionsMethod PerformanceAdditional TechniquesTriazolamBackgroundMethod 1ExtractionGC/MS ConditionsMethod PerformanceMethod 2ExtractionGC/MS ConditionsMethod PerformanceReferencesChapter 5Identification of Benzodiazepines in Human Hair: A ReviewVincent Cirimele and Pascal KintzIntroductionBiology of HairHair GrowthTypes of HairMechanisms of Drug Incorporation into HairEffects of Cosmetic TreatmentsSpecimen CollectionDecontamination ProceduresExtractionDetectionDetection of Flunitrazepam and 7-Amino-FlunitrazepamConclusionsReferencesChapter 6g-Hydroxybutyric Acid and Its Analogs, g-Butyrolactone and 1,4-ButanediolLaureen J. MarinettiHistory and Pharmacology of GHBHistory of Illicit Use of GHBClinical Use of GHB in HumansHistory of Illicit Use of GBL and 1,4BDMetabolism of GHB, GBL, and 1,4BDDistribution and Pharmacokinetics of GHB, GBL, and 1,4BDGHB Interpretation Issues and Postmortem ProductionAnalysis for GHB, GBL, and 1,4BDReferencesChapter 7Analysis of Urine Samples in Cases of Alleged Sexual Assault: Case HistoryMahmoud A. ElSohly, Luen F. Lee, Lynn B. Holzhauer, and Salvatore J. SalamoneIntroductionReferencesIndex

Editorial Reviews

"...this work is of value. It provides toxicologists with important information, and, since most of its authors are respected forensic toxicologists (P. Kintz, M. Elsohly, D. Crouch, etc.), its content is highly appropriate to forensic toxicology. It reads easily and should find a choice place on shelves of toxicologists interested in the detection and pharmacology of benzos and GHB in forensic cases, especially those relating to sexual assaults." - Canadian Society of Forensic Science Journal