Between The Lines Of Genetic Code: Genetic Interactions In Understanding Disease And Complex…

Hardcover | October 23, 2013

byLeonid PadyukovEditorLeonid Padyukov, Lars Alfredsson

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Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care. Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases. Systematically integrates methods of defining and detecting gene interactions to provide an overview of the field Critically analyzes current methods and tools to aid researchers in integrating gene interaction studies Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future

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From the Publisher

Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current st...

Format:HardcoverDimensions:232 pages, 9 × 6 × 0.98 inPublished:October 23, 2013Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123970172

ISBN - 13:9780123970176

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Table of Contents

1. Introduction 2. Terminology and definitions for interaction studies 3. Multidimensional reduction in study of interaction 4. Study design for interaction 5. High throughput interaction study 6. Conclusions for the section 7. Interaction in study of human complex diseases: Rheumatoid arthritis 8. Interaction in study of human complex diseases: Multiple sclerosis 9. Interaction in study of human complex diseases: Myositis 10. Interaction in study of human complex diseases: other 11. Conclusions for the section 12. Functional studies of detected interactions in rheumatoid arthritis 13. Complex patterns of interaction, genetic vectors 14. From detection to understanding: pathways and networks 15. Conclusions for the section 16. Conclusions for the book

Editorial Reviews

"Specialists in genetic epidemiology and human genetics, most at the Karolinski Institute in Stockholm, review the current status of the field and clarify the main definitions, recent findings, and future directions. They consider such topics as reducing dimensionality in the search for gene-gene interactions, high-throughput genetic interaction studies, gene-gene and gene-environment interaction in rheumatoid arthritis."--ProtoView.com, February 2014 "This book presents methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies of human diseases such as rheumatoid arthritis, multiple sclerosis, myositis, and other complex disorders.This is an excellent book on genetic interactions. Students, researchers, molecular biologists, and geneticists will find it quite useful." Rating: 3 Stars--Doody.com, January 24, 2014