Bile Acids: Biological Actions and Clinical Relevance by D. KepplerBile Acids: Biological Actions and Clinical Relevance by D. Keppler

Bile Acids: Biological Actions and Clinical Relevance

EditorD. Keppler, U. Beuers, U. Leuschner

Hardcover | June 22, 2007

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Since the last International Bile Acid Meeting in Stockholm in 2004, bile acid research has continued to flourish and therapeutic use of bile acids has attained a broader role. New insights have been gained into the mechanisms responsible for maintenance of bile acid homeostasis, and effects of bile acids on the cell signalling pathways have been further elucidated. Knowledge of the genetic basis of bile acid physiology has further increased. Therapy of chronic cholestatic liver diseases with ursodeoxycholic acid and new aspects of its chemopreventive properties continue to stimulate basic and clinical research and contribute to the understanding of underlying modes of action and to optimized treatment schedules.Chapters reflect the recent progress in bile acid metabolism and transport, nuclear receptor regulation and signaling by bile acids, as well as mechanisms of bile acid-induced cellular injury. Bile acids as therapeutic agents, particularly for the treatment of cholestatic liver diseases, are the focus of several clinically oriented contributions. This volume in the Falk Symposium series therefore contributes successfully to the bridging of basic science and clinical hepatology in the field of bile acids.
Title:Bile Acids: Biological Actions and Clinical RelevanceFormat:HardcoverDimensions:287 pagesPublished:June 22, 2007Publisher:Springer NetherlandsLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1402062516

ISBN - 13:9781402062513

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Table of Contents

List of principal contributors. List of chairpersons. Preface.- Section I: Metabolism Of Bile Acids.- Section II: Hepatobiliary Transport Of Bile Acids.- Section III: Extrahepatocytic Transport And Actions Of Bile Acids.- Section IV: Nuclear Receptor Regulation.- Section V: Bile Acids, Cellular Injury, And Disease Mechanisms.- Section VI: Bile Acids, Cellular Injury, And Hepatic Fibrosis.- Section VII: Bile Acids As Therapeutic Agents: Mechanisms And Actions.- Section VIII: Bile Acids In The Treatment Of Cholestatic Liver Disease.- Index.