Bioactive Heterocycles IV by Mahmud T.H. KhanBioactive Heterocycles IV by Mahmud T.H. Khan

Bioactive Heterocycles IV

byMahmud T.H. Khan

Hardcover | October 11, 2007

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This volume contains nine more contributions from expert researchers of the ?eld, providing readers with in depth and current research results regarding therespective topics. In the ?rst chapter, Flemming et al. review the chemistry, biosynthesis, metabolism and biological activities of tetrahydrocannabinol and its deri- tives. Hansch and Verma contribute to the quantitative structure-activity re- tionship (QSAR) analysis of heterocyclic topoisomerase I and II inhibitors. These inhibitors,knowntoinhibit either enzyme, actasantitumoragentsand are currently used in chemotherapy and in clinicaltrials. In the third chapter, Khan reviews some aspects of molecular modeling studies on biologically active alkaloids, brie?y providing considerations on themodeling approaches. In next chapter, Khan and Ather review different aspects of the microbial transformationsof theimportant nitrogenousmolecules, as they have diverse biological activities. This chapter provides a critical update of the microbial transformations reported in recent years, targeting novel biocatalysts from microbes. In the ?fth chapter, Hamdi and Dixneuf describe the synthesis of triazoles andcoumarins molecules andtheirphysiologicalactivities. Maiti and Kumar, in their contribution, review the physicochemical and nucleic acid binding properties of several isoquinoline alkaloids (berberine, palmatine and coralyne) and their derivatives under various environmental conditions. Inchapterseven,Berlinckdescribesvarietiesofpolycyclicdiaminealkaloids such as halicyclamines, 'upenamide, xestospongins, araguspongines, hali- clamines, haliclonacyclamines, arenosclerins, ingenamines and the mad- gamines, etc.,and their synthesis as well as biologicalactivities.
Title:Bioactive Heterocycles IVFormat:HardcoverProduct dimensions:317 pages, 23.5 × 15.5 × 0.02 inShipping dimensions:23.5 × 15.5 × 0.02 inPublished:October 11, 2007Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3540734031

ISBN - 13:9783540734031

Reviews

Table of Contents

T. Flemming, R. Muntendam, C. Steup, O. Kayser: Chemistry and Biological Activity of Tetrahydrocannabinol and its Derivatives.- C. Hansch, R.P. Verma: Quantitative Structure-Activity Relationships of Heterocyclic Topoisomerase I and II Inhibitors.- M.T.H. Khan: Molecular Modeling of the Biologically Active Alkaloids - A Critical Review.- M.T.H. Khan, A. Ather: Microbial Transformation of Nitrogenous Compounds - An Update N. Hamdi, P.H. Dixneuf: Synthesis of Triazoles and Coumarins Compounds and Their Physiological Activity.- M. Maiti, G.S. Kumar: Protoberberine Alkaloids: Physicochemical and Nucleic Acid Binding Properties.- R.G.S. Berlinck: Polycyclic Diamine Alkaloids from Marine Sponges.- P. Buzzini, B. Turchetti, F, Ieri, M. Goretti, E. Branda, N. Mulinacci, A. Romani: Catechins and Proanthocyanidins: Naturally Occurring O-heterocycles with Antimicrobial Activity.- H. Cerecetto, M. González: Benzofuroxan and Furoxan. Chemistry and Biology

Editorial Reviews

From the reviews:"This latest volume in the series Topics in Heterocyclic Chemistry is a collection of nine chapters covering a diverse assortment of natural and synthetic nitrogen- and oxygen- containing heterocycles. . A Subject Index and an Author Index for Volumes 1-10 are included. . the structural drawings are excellent. . to academic libraries that are collecting volumes from the Topics in Heterocyclic Chemistry series." (Gordon W. Gribble, Journal of the American Chemical Society, Vol. 130 (19), 2008)