Biochemistry and Genetics of Recq-Helicases by David B. LombardBiochemistry and Genetics of Recq-Helicases by David B. Lombard

Biochemistry and Genetics of Recq-Helicases

byDavid B. Lombard

Paperback | October 30, 2012

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Biochemistry And Genetics of RecQ-Helicasesprovides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.
Title:Biochemistry and Genetics of Recq-HelicasesFormat:PaperbackDimensions:92 pagesPublished:October 30, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1461355370

ISBN - 13:9781461355373

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Table of Contents

Dedication. Contents. Figures. Preface. Acknowledgments. 1. The RecQ-family helicases. 2. Targeting the WRN locus in the mouse. 3. Interaction of the BLM protein with Topo III alpha in somatic, meiotic cells. 4. Nijmegen breakage syndrome disease protein and Mre 11 at PML nuclear bodies, meiotic telomeres. Bibliography. Subject Index.