Biofilm-Based Nosocomial Infections by Gianfranco DonelliBiofilm-Based Nosocomial Infections by Gianfranco Donelli

Biofilm-Based Nosocomial Infections

Guest editorGianfranco Donelli

Hardcover | December 31, 2015

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The well-known persistence in the nosocomial environment of multidrug resistant bacterial
and fungal species, today responsible for a wide variety of healthcare-associated infections, is
believed to be greatly promoted by the ability of most of them to adhere and to grow in sessile
mode on mucosal and soft tissues of hospitalized patients, as well as on the inner and outer
surfaces of indwelling medical devices, including intravenous catheters, orthopaedic, cardiac
valves, intrauterine devices, and contact lenses.
In this regard, a large number of these microorganisms, such as Acinetobacter baumannii,
Candida albicans, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and
Staphylococcus aureus, give rise to highly organized, sessile community defined biofilms, in
which microbes grow encased in a hydrated matrix of extracellular polymeric substances
produced by themselves and are well protected from the attack of antimicrobial molecules and
from the host immune response, by resisting phagocytosis and other body's defense systems.
The great influence of the sessile growth on the effectiveness of the antibiotic therapies is due
to both the structure and function of these microbial communities, making these also 1000
times more tolerant to antibiotics and disinfectants. Thus, alternative approaches to the
common antibiotic treatments are emerging for preventing and treating both the mono-species
and the most frequent multi-species biofilms, including enzymes able to disrupt mature
biofilms and new biomaterials for the coating of medical devices to counteract microbial
adhesion and biofilm formation.
The aim of this Special Issue is to report on the state-of-art of the basic and applied research
in the field of biofilm-based nosocomial infections that can be acquired by patients in both
general hospitals and long-term care settings. Particularly, the involvement of microbial
biofilms in medical device-related infections and other healthcare-associated infections, so far
underestimated and/or scarcely investigated, has been considered, reviewed, and discussed.

Title:Biofilm-Based Nosocomial InfectionsFormat:HardcoverProduct dimensions:238 pages, 9.61 × 6.69 × 0.81 inShipping dimensions:9.61 × 6.69 × 0.81 inPublished:December 31, 2015Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038421359

ISBN - 13:9783038421351


Table of Contents

Biomolecular Mechanisms of Pseudomonas aeruginosa and Escherichia coli Biofilm FormationIron and Acinetobacter baumannii Biofilm FormationPseudomonas aeruginosa Diversification during Infection Development in Cystic FibrosisLungs-A ReviewAntibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniaeExploring Dangerous Connections between Klebsiella pneumoniae Biofilms and Healthcare-Associated InfectionsBiofilms in Infections of the EyeRole of Daptomycin in the Induction and Persistence of the Viable but Non-Culturable Stateof Staphylococcus aureus BiofilmsEvolution of Antimicrobial Peptides to Self-Assembled Peptides for Biomaterial ApplicationsAntimicrobial Activity of Selected Phytochemicals against Escherichia coli and Staphylococcus aureus and Their BiofilmsAntibiofilm Effect of Octenidine Hydrochloride on Staphylococcus aureus, MRSA and VRSAAntimicrobial and Antibiofilm Activity of Chitosan on the Oral Pathogen Candida albicans