Biomarker Methods in Drug Discovery and Development by Feng WangBiomarker Methods in Drug Discovery and Development by Feng Wang

Biomarker Methods in Drug Discovery and Development

EditorFeng Wang

Paperback | November 9, 2010

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In this book, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols. This book is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.
Title:Biomarker Methods in Drug Discovery and DevelopmentFormat:PaperbackDimensions:414 pages, 9.25 × 6.1 × 0.68 inPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617379255

ISBN - 13:9781617379253

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Table of Contents

Table of ContentPrefaceContributorsChapter 1 Biomarker sample collection and handling in the clinical setting to support early phase drug developmentChris B. Russell, Sid Suggs, Kristina M. Robson, Keith Kerkof, Lisa D. Kivman, Kimberly H. Notari, William A. Rees, Natalia Leshinsky, and Scott D. PattersonChapter 2 Gene Expression-Based Biomarkers of Drug SafetyEric A.G. Blomme, and Scott E. WarderChapter 3 Profiling Gene Expression Signatures Using Fluorescent MicrospheresSuzanne M. Torontali, Jorge M. Naciff, Kenton D. Juhlin, and Jay P. TiesmanChapter 4 Real-Time PCR Gene Expression Assays in Biomarker Discovery and ValidationYulei Wang, Catalin Barbacioru, David Keys, Pius Brzoska, Caifu Chen, Kelly Li, and Raymond R. SamahaChapter 5 SAGE Analysis in Identifying Phenotype SNPsSandro J. de Souza, I-Mei Siu, Janete M. Cerutti, and Gregory J. RigginsChapter 6 SNP and DNA Methylation Analysis using Pyrosequencing MethodsJinsheng Yu, and Sharon MarshChapter 7 The Application of LCM for the Analysis of Specific Cell-Type GeneExpression in a Complex Tissue: the Primate EndometriumWilliam C. OkuliczChapter 8 The use of Two-Dimensional Gel Electrophoresis for Plasma Biomarker Discovery Brad Jarrold, Alex Varbanov, and Feng WangChapter 9 Difference In Gel Electrophoresis (DIGE), a high resolution protein biomarker research toolDavid S. Gibson, David Bramwell, and Caitriona ScaifeChapter 10 Label-free Mass Spectrometry-based Protein Quantification Technologies in Protein Biomarker DiscoveryMu Wang, Jin-Sam You, Kerry G. Bemis, and Dawn P. G. FitzpatrickChapter 11 Top-Down Quantitative Proteomic Analysis using a Highly Multiplexed Isobaric Mass Tagging Strategy Bing Xie, Wayne F. Patton, and Craig E. ParmanChapter 12 SELDI Technology for Identification of Protein BiomarkersPrasad Devarajan, and Gary F. RossChapter 13 Sandwich ELISA Microarrays: Generating Reliable and Reproducible Assays for High Throughput ScreensRachel M Gonzalez, Susan M Varnum, and Richard C ZangarChapter 14 LC-MS Metabonomics Methodology in Biomarker DiscoveryXin Lu, and Guowang XuChapter 15 GC/MS-based metabolomicsSally-Ann Fancy, and Klaus RumpelChapter16 NMR-Based Metabolomics for Biomarker DiscoveryNarasimhamurthy Shanaiah, Shucha Zhang, M. Aruni Desilva, and Daniel RafteryChapter 17 Unraveling Glycerophospholipidomes by LipidomicsKim EkroosIndex

Editorial Reviews

From the reviews:"... extremely useful to pharmaceutical scientists who are involved in research all the way from early drug discovery through clinical trials." - Doody's Book Review"The book is . for the bench scientist and is full of helpful advice on how to achieve high quality data using up-to-date technical approaches in genomics, proteomics and metabonomics. . I warmly recommend this . to all practicing toxicologists." (Roy Forster, British Toxicological Society Newsletter, June-August, 2009)