Biomarkers in Breast Cancer by Giampietro GaspariniBiomarkers in Breast Cancer by Giampietro Gasparini

Biomarkers in Breast Cancer

EditorGiampietro Gasparini

Paperback | December 1, 2010

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Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

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Title:Biomarkers in Breast CancerFormat:PaperbackDimensions:354 pages, 9.02 × 5.98 × 0.07 inPublished:December 1, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617374369

ISBN - 13:9781617374364

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Table of Contents

Part I. General TopicsGuidelines for the Design of Clinical Studies for the Development and Validation of Therapeutically Relevant Biomarkers and Biomarker-Based Classification SystemsRichard M. SimonAnalytical Aspects of Biomarker Immunoassays in Cancer ResearchFred C. G. J. Sweep, Chris M. G. Thomas, and Manfred SchmittTissue Microarrays: State of the Art, Pitfalls, and PromisesChungyeul Kim and Soonmyung PaikPart II. Assays for Gene Expression and Post-Translational Protein AbnormalitiesGene Expression Profiling with DNA Microarrays: Revolutionary Tools to Help Diagnosis, Prognosis, Treatment Guidance, and Drug DiscoveryMichele De Bortoli and Nicoletta BigliaPart III. Assays for DNA AbnormalitiesAssays for Gene Amplification: State of the Art, Pitfalls, and PromisesChungyeul Kim, Yongkuk Song, and Soonmyung PaikPart IV. Tissue Predictive BiomarkersCell KineticsMaria Grazia Daidone, Rosella Silvestrini, and Dino AmadoriUrokinase-Type Plasminogen Activator and PAI-1: Validated Prognostic Factors for Breast CancerMichael J. DuffyPredictive Value of c-erb-B2 for Endocrine Therapy and Chemotherapy in Breast CancerVered Stearnserb-B2 as a Therapeutic TargetRobert MassThe Epidermal Growth Factor Receptor Pathway as a Selective Molecular-Targeted Treatment in Human Breast CancerFortunato Ciardiello, Teresa Troiani, and Giampaolo Tortorap53 as a Prognostic and Predictive IndicatorDaniela Kandioler and Raimund JakeszPart V. Predictive Biomarkers in Body FluidsOccult Metastatic Cells in Breast Cancer Patients: State of the Art, Pitfalls, and PromisesStephan Braun, Julia Seeber, and Christian MarthCirculating HER2/neu: Clinical UtilityAllan Lipton, Laurence Demers, Kim Leitzel, Suhail M. Ali, Rainer Neumann, Christopher P. Price, and Walter P. CarneyCirculating Vascular Endothelial Growth Factor: Methods, Prognostic Significance, and Potential Application for Antiangiogenic TherapyRoberta Sarmiento, Roberta Franceschini, Sabrina Meo, Massimo Gion, Raffele Longo, and Giampietro GaspariniDetection of Early Tumor Dissemination in Patients with Breast CancerDebra Hawes and Richard J. CotePart VI. Future DirectionsNew Technologies/New Markers/New ChallengesDaniel F. Hayes and Giampietro GaspariniIndex