Biomechanics of the Human Urinary Bladder by Roustem N. MiftahofBiomechanics of the Human Urinary Bladder by Roustem N. Miftahof

Biomechanics of the Human Urinary Bladder

byRoustem N. Miftahof, Hong Gil Nam

Hardcover | February 4, 2013

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As a research subject, the biomechanics of the urinary bladder are relatively young, yet medical problems associated with them are as old as mankind. Offering an update on recent achievements in the field, the authors highlight the underlying biological, chemical and physical processes of bladder function and present the systematic development of a mathematical model of the organ as a thin, soft biological shell. The book will be a valuable resource for postgraduate students and researchers interested in the applications of computational mathematics and solid mechanics to modern problems in biomedical engineering and medicine.

Title:Biomechanics of the Human Urinary BladderFormat:HardcoverDimensions:177 pagesPublished:February 4, 2013Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642361455

ISBN - 13:9783642361456

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Table of Contents

1 The Bladder as a Dynamic System

1.1 Anatomy of the human urinary bladder

1.2 Detrusor muscle

1.2.1 Morphology of smooth muscle

1.2.2 Electromechanical activity of the detrusor

1.2.3 Pacemaker activity

1.3 Neurohormonal regulatory system

1.3.1 Anatomical considerations

1.3.2 Neurotransmission

1.3.3 Electrophysiological characteristics of neurons

1.4 Morphofunctional states in the bladder

1.4.1 Bladder filling

1.4.2 Bladder voiding


2 .Investigations into Biomechanics of the Bladder

2.1 Biomechanics of the detrusor

2.2 Modelling of the bladder


3 Geometry of Thin Shells

3.1 The bladder as a thin biological shell

3.2 Geometry of the shell

3.3 Tensor of affine deformation

3.4 Equations of continuity of deformations

3.5 Equations of equilibrium


4 Essentials of the Theory of Soft Shells

4.1 Deformation of the shell

4.2 Principal deformations

4.3 Membrane forces

4.4 Principal membrane forces

4.5 Equations of motion in general curvilinear coordinates

4.6 Nets

4.7 Corollaries of the fundamental assumptions


5 Continual Model of the Detrusor

5.1 Basic assumptions

5.2 Model formulation

5.3 Biofactor

5.4 Special cases


6 A Model of the Detrusor Fasciculus

6.1 Formulation of the model

6.2 Physiological condition

6.3 Effects of pharmacological and extracellular ion changes on electromechanical activity of the detrusor

6.3.1 Changes in

6.3.2 L- and T-type channel antagonists

6.3.3 BKCachannel agonist/antagonist

6.3.4 K+channel agonist/antagonist

6.3.5 - ATPase inhibitors


7 The Intrinsic Regulatory Pathways

7.1 Models of electrical activity of neurons

7.2 A model of neuronal assembly in the bladder

7.3 Response of the detrusor to stretching

7.4 Pharmacology of the neuronal pathway

7.4.1 Effect of iberiotoxin and charybdotoxin

7.4.2 Effect of Ï-CgTX

7.4.3 Effect of TTX

7.4.4 Effect of purinoceptor agonists

7.4.5 Effect of protein kinase C activator


8 The Synaptic Transmission

8.1 A model of the synapse

8.2 cAMP-dependent pathway

8.3 PLC-dependent pathway

8.4 Physiological response

8.5 Variations in synaptic neurotransmission

8.5.1 Chloride salts of divalent cations

8.5.2 Change in [ ]

8.5.3 b - bungarotoxin

8.5.4 Botulinum toxin

8.5.5 Tetrodotoxin

8.5.6 High frequency stimulation

8.5.7 Inhibition of neuronal uptake-1 mechanism


9 Pharmacology of Detrusor Activity

9.1 Classes of drugs

9.2 Current pharmacological therapies of bladder dysfunction

9.3 Model of competitive antagonist action

9.4 Model of allosteric interaction

9.5 Allosteric modulation of competitive agonist/antagonist action

9.6 Effect of cholinergic antagonists/agonists

9.7 Inhibition of catechol-O-methyltransferase

9.8 Effect ofb- adrenoceptor antagonists


10 Human Urinary Bladder as a Soft Biological Shell

10.1 Basic assumptions

10.2 Model of the bladder

10.3 Bladder mechanics

10.3.1 Filling stage

10.3.2 Voiding stage

10.3.3 Pharmacological modulation of voiding

11 Challenges in Human Urinary Bladder Mechanics

11.1 Urine-bladder interaction

11.2 Brain-bladder axis

11.3 Bladder substitutes