Biomedical EPR - Part A: Free Radicals, Metals, Medicine and Physiology: Free Radicals, Metals, Medicine and Physiology by Sandra S. EatonBiomedical EPR - Part A: Free Radicals, Metals, Medicine and Physiology: Free Radicals, Metals, Medicine and Physiology by Sandra S. Eaton

Biomedical EPR - Part A: Free Radicals, Metals, Medicine and Physiology: Free Radicals, Metals…

EditorSandra S. Eaton, Gareth R. Eaton, Lawrence J. Berliner

Hardcover | August 19, 2004

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Biomedical EPR - Part A focuses on applications of EPR spectroscopy in the areas of free radicals, metals, medicine, and physiology. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field which lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR. Key Features:Free Radicals in Medicine Radicals in vivo and in Model Systems, and their Study by Spin Trapping In vivo EPR, including Oximetry and Imaging Time Domain EPR at Radio Frequencies EPR of Copper Complexes: Motion and Frequency Dependence Time Domain EPR and Electron Spin Echo Envelope Modulation
Prof. Sandra S. Eaton is John Evans Professor in the Department of Chemistry and Biochemistry at the University of Denver. Her research interests include distance measurements in proteins, EPR of metal ions in biological systems, electron spin relaxation times, and EPR instrumentation. The Eatons co-organize an annual EPR Symposium in ...
Title:Biomedical EPR - Part A: Free Radicals, Metals, Medicine and Physiology: Free Radicals, Metals…Format:HardcoverDimensions:546 pages, 9.02 × 5.98 × 0.09 inPublished:August 19, 2004Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0306485060

ISBN - 13:9780306485060

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Table of Contents

Section I. Instrumentation and MethodologyChapter 1Saturation Recovery EPR; Sandra S. Eaton and Gareth R. Eaton1. Motivation 2. Brief History3. Information Content of Saturation Recovery Curves4. Practical Aspects of Experimental Methodology5. Applications6. Prognosis7. ReferencesChapter 2 Loop-Gap Resonators; George A. Rinard and Gareth R. Eaton1. Introduction2. History3. Why should one use loop-gap resonators?4. Basics5. Topologies of loop gap resonators6. Coupling to Resonators7. Design equations8. Magnetic Field Modulation9. LGR for Time Domain EPR10. Selection of the Q of a LGR11. Measuring B1 in the LGR12. Variable Temperature13. Mechanical Considerations14. Commercial Resonators15. Applications of Lumped-Circuit Resonators16. Further information17. ReferencesChapter 3EPR Interfaced To Rapid Mixing; Charles P. Scholes1. Introduction2. The Loop Gap Resonator Based Stopped-Flow System3. Dielectric Resonator-based Stopped-Flow EPR4. Applications of Stopped-Flow and Flow EPR to Naturally Occurring Transient Radicals5. Future Developments and Applications of Flow and Stopped-Flow EPR6. ReferencesChapter 4 Application of Angle-Selected Electron Nuclear Double Resonance to Characterize Structured Solvent in Small Molecules and Macromolecules; Devkumar Mustafi and Marvin W. Makinen1. Introduction 2. ENDOR Assignment of Molecular Structure and Conformation with VO2+ and Nitroxyl Spin-Labels 3. ENDOR Characterization of Structured Solvent in Small Molecule Complexes and in Proteins 4. Future Perspectives and Concluding Remarks5. ReferencesChapter 5Solution-ENDOR of Some Biologically Interesting Radical Ions; Fabian Gerson and Georg Gescheidt1. Solution ENDOR Spectroscopy 2. Quinones3. Porphyrinoids4. References Chapter 6Electron-Electron Double Resonance; Lowell D. Kispert1. Introduction 2. Instrumental Techniques 3. Dynamics of Biomolecules in Liquid Crystals, Glassy Solids, Polymers and Crystals 4. Practical Aspects of Measurements5. ReferencesChapter 7 Digital Detection by Time-Locked Sampling in EPR; James S. Hyde, Theodore G. Camenisch, Joseph J. Ratke, Robert A. Strangeway, Wojciech Froncisz1. Introduction 2. Time Locking and Superheterodyne Detection - EPR Instrument Design Background 3. Time-Locked Subsampling Detection for CW EPR4. Pulse Saturation Recovery Using Time-Locked Subsampling5. Selected Engineering Considerations6. Conclusion7. References Chapter 8Measurement of Distances Between Electron Spins Using Pulsed EPR; Sandra S. Eaton and Gareth R. Eaton1. Introduction2. Fundamental Principles of Interaction between Electron Spins3. Distance between Two Slowly Relaxing Centers4. Distance between a Slowly Relaxing Center and a Rapidly-Relaxing Center 5. Some Practical Considerations6. Recent Examples for Distances between Two Slowly-Relaxing Radicals 7. Recent Examples for Distances between a Rapidly-Relaxing and a Slowly-Relaxing Spin8. Prognosis9. References Section II. Motion, Proteins, and Membranes Chapter 9ESR and Molecular Dynamics; Jack H. Freed1. Motional Narrowing and Organic Radicals 2. Double Resonance and Molecular Dynamics 3. Slow Motional ESR and Molecular Dynamics4. High Field ESR and Molecular Dynamics 5. Spin-Echoes and Molecular Dynamics6. Two-Dimensional Fourier Transform ESR7. Prospectus8. Glossary of Abbreviations 9. ReferencesChapter 10SDSL: A Survey of Biological Applications; Candice S. Klug and Jimmy B. Feix1. Introduction2. Solvent accessibility 3. Motion 4. Distance measurements 5. Methodology 6. Conclusion 7. References Chapter 11Saturation Transfer Spectroscopy of Biological Membranes; Derek Marsh, László I. Horváth, Tibor Páli And Vsevolod A. Livshits1. Introduction 2. Historical Development 3. Rapid-Passage Saturation-Transfer-EPR Displays4. Modulation-Coupled Bloch Equations5. Slow Rotational Diffusion6. Applications: Slow Rotation7. T1-Sensitive Nonlinear EPR Displays8. Slow Exchange and Paramagnetic Enhancements9. Applications: Relaxation Enhancements10. Outlook 11. References Chapter 12 Saturation Transfer EPR: Rotational Dynamics of Membrane Proteins; Albert H. Beth and Eric J. Hustedt1. Introduction2. Methods for Analysis of ST-EPR Data 3. Overview of Theory for Calculation of ST-EPR Spectra 4. Nonlinear Least Squares Methods of Data Analysis 5. Model Calculations of ST-EPR Spectra Using the Transition Rate Matrix Approach6. Applications of ST-EPR to Membrane Proteins7. ReferencesChapter 13Trends in EPR Technology; James S. Hyde 1. Introduction2. Resonators3. Noise4. Multifrequency EPR5. EPR for Routine Analysis6. Discussion7. ReferencesChapter 14Prognosis; Sandra S. Eaton and Gareth R. Eaton Contents of Previous VolumesIndex