Biomedical Optical Imaging

Hardcover | April 22, 2009

byJames G. Fujimoto, Daniel Farkas

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Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques andapplications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technologywith exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to themacroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep insidebiological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.

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Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques andapplications. A unique research field span...

James G. Fujimoto is Professor of Electrical Engineering and Computer Science at the Massachusetts Institute of Technology, where he works on the development and application of femtosecond laser technology and studies ultrafast phenomena and biomedical optics. He received his bachelors, masters, and doctorate degrees from M.I.T. ...

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Format:HardcoverDimensions:416 pages, 10 × 7 × 0.98 inPublished:April 22, 2009Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195150449

ISBN - 13:9780195150445

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Table of Contents

James G. Fujimoto and Daniel L. Farkas: Preface1. Tony Wilson: Confocal Microscopy2. Kevin Burton, Jihoon Jeong, Sebastian Wachsmann-Hogiu and Daniel L. Farkas: Spectral Optical Imaging in Biology and Medicine3. Fritjof Helmchen, Samuel S.-H. Wang, and Winifred Denk: Multi-photon Microscopy in Neuroscience4. Dahlene Fusco, Edouard Bertrand, and Robert H. Singer: mRNA Imaging in Living Cells for Biomedical Research5. Alan S. Waggoner, Lauren A. Ernst, and Byron Ballou: Building New Fluorescent Probes6. Dejan Vucinic, Efstratios Kosmidis, Chun X. Falk, Lawrence B. Cohen, Leslie M. Loew, Maja Djurisic, and Dejan Zecevic: Imaging Membrane Potential with Voltage-Sensitive Dyes7. James Fujimoto, Yu Chen, and Aaron Aguirre: Biomedical Imaging using Optical Coherence Tomography8. Petra Schwille, Katrin Heinze, Petra Dittrich, and Elke Haustein: Two-Photon Fluorescence Correlation Spectroscopy9. Stefan W. Hell and Andreas Schonle: Nanoscopy: The Future of Optical Microscopy10. S. Andersson-Engels, K. Svanberg, and S. Svanberg: Fluorescence Imaging in Medical Diagnostics11. Adam Wax, Vadim Backman, Changhuei Yang, and Michael S. Feld: Light Scattering Spectroscopic Techniques for Examining Cellular Structure, Organization and Dynamics12. I. Pavlova, R. Drezek, S. Chang, D. Arifler, K. Sokolov, C. MacAulay, M. Follen, and R. Richards-Kortum: Fluorescence and Spectroscopic Markers of Cervical Neoplasia13. Dorota Jakubowski, Frederic Bevilacqua, Sean Merritt, Albert Cerussi, and Bruce J. Tromberg: Quantitative Absorption and Scattering Spectra in Thick Tissues using Broadband Diffuse Optical Spectroscopy14. Enrico Gratton, Vlad Toronov, Ursula Wolf, and Martin Wolf: Detection of Brain Activity by Near-Infrared Light15. Vasilis Ntziachristos and Ralph Weissleder: In-Vivo Optical Imaging of Molecular Function using NIR Fluorescent Probes