Biometals In Neurodegenerative Diseases: Mechanisms And Therapeutics by Anthony R. White

Biometals In Neurodegenerative Diseases: Mechanisms And Therapeutics

byAnthony R. WhiteEditorMichael Aschner, Lucio G. Costa

Hardcover | April 28, 2017

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Biometals in Neurodegenerative Diseases: Mechanisms and Therapeuticsis an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.

This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.

Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.



  • Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets
  • Written for academic researchers, clinicians and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology
  • Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

About The Author

Associate Professor Anthony White is a Group Leader at the QIMR Berghofer Medical Research Institute in Queensland, Australia. He is also an Honorary Principal Research Fellow at The University of Melbourne, and an Adjunct Professor in Translational Neuroscience at A.I. Virtanen Institute, University of Eastern Finland. He investigates...
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Details & Specs

Title:Biometals In Neurodegenerative Diseases: Mechanisms And TherapeuticsFormat:HardcoverDimensions:462 pages, 9.41 × 7.24 × 0.98 inPublished:April 28, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128045620

ISBN - 13:9780128045626

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Table of Contents

1. Biometals and Alzheimer's Disease 2. Copper in Alzheimer's Disease 3. The Role of Selenium in Neurodegenerative Diseases 4. Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response? 5. Chemical Elements and Oxidative Status in Neuroinflammation 6. Metals and Neuroinflammation 7. Metals and Prions: Twenty Years of Mining the Awe 8. Manganese and Neurodegeneration 9. Zinc in Autism 10. Metals and Motor Neuron Disease 11. Metals and Lysosomal Storage Disorders 12. Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration 13. Metal Biology Associated with Huntington's Disease 14. Metal-Binding to Amyloid-ß Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production 15. Metals and Mitochondria in Neurodegeneration 16. Metal Transporters in Neurodegeneration 17. Metal Imaging in the Brain 18. Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases 19. Metals and Autophagy in Neurotoxicity 20. An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases 21. Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases