Biometals In Neurodegenerative Diseases: Mechanisms And Therapeutics

Hardcover | June 1, 2017

byAnthony R. WhiteEditorMichael Aschner, Lucio G. Costa

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Biological metals biometals have key functions in the brain but can also induce degenerative changes due to abnormalities in homeostatic mechanisms. The scientific literature in this field is advancing rapidly with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and others. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in the brain function, disease and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism, and lysosomal storage disorders. This book is written for academic researchers, clinicians, and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology, and neurotoxicology Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease and as therapeutic targets Written for academic researchers, clinicians, and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology, and neurotoxicology Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

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Biological metals biometals have key functions in the brain but can also induce degenerative changes due to abnormalities in homeostatic mechanisms. The scientific literature in this field is advancing rapidly with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases ...

From the Jacket

Biological metals (biometals) have key functions in the brain but can also induce degenerative changes due to abnormalities in homeostatic mechanisms. The scientific literature in this field is advancing rapidly with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative disease...

Associate Professor Anthony White is a Group Leader at the QIMR Berghofer Medical Research Institute in Queensland, Australia. He is also an Honorary Principal Research Fellow at The University of Melbourne, and an Adjunct Professor in Translational Neuroscience at A.I. Virtanen Institute, University of Eastern Finland. He investigates...

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Format:HardcoverDimensions:350 pages, 9.41 × 7.24 × 0.98 inPublished:June 1, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128045620

ISBN - 13:9780128045626

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Table of Contents

1. Biometals and Alzheimer's Disease
2. Copper in Alzheimer's Disease
3. The Role of Selenium in Neurodegenerative Diseases
4. Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?
5. Chemical Elements and Oxidative Status in Neuroinflammation
6. Metals and Neuroinflammation
7. Metals and Prions: Twenty Years of Mining the Awe
8. Manganese and Neurodegeneration
9. Zinc in Autism
10. Metals and Motor Neuron Disease
11. Metals and Lysosomal Storage Disorders
12. Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration
13. Metal Biology Associated with Huntington's Disease
14. Metal-Binding to Amyloid-ß Peptide: Coordination, Aggregation and Reactive Oxygen Species Production
15. Metals and Mitochondria in Neurodegeneration
16. Metal Transporters in Neurodegeneration
17. Metal Imaging in the Brain
18. Metalloregulation of Protein Clearance: New Therapeutics Avenues for Neurodegenerative Diseases
19. Metals and Autophagy in Neurotoxicity
20. An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases
21. Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases