Bioorganic Chemistry: Nucleic Acids

Hardcover | September 1, 1993

EditorSidney M. Hecht

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Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into the workings of biological systems at a molecular level. Recently, this growing field has witnessed some very exciting results inapplying design and synthesis techniques to many problems in molecular biology. Much of the current work in areas such as protein folding, signal transduction, molecular recognition, monoclonal antibodies, and drug design is being conducted by bioorganic chemists. Bridging the gap between chemistryand biology, Topics in Bioorganic and Biological Chemistry, A Series of Books in Support of Teaching and Research is a novel resource designed to serve the needs of the many graduate students, professionals, and researchers who work and study in these fields by concisely summarizing a range oftopics which constitute the core of expertise in this emerging discipline. This first volume, Bioorganic Chemistry: Nucleic Acids provides an overview of DNA and RNA, including coverage of biosynthesis, structure, and their functions in information storage and transmission. Special emphasis is given to the manner in which the individual chemistries of DNA and RNA conduceto their specific functions. The chemistry of molecules that disrupt nucleic acid biosynthesis and functions, antisense technologies involving RNA and DNA, and naturally occurring ribozymes are also covered. Each chapter begins with an introduction that includes basic principles, a summary of keyfindings which support current research in the field, and an overview of current research activity. The remainder of each chapter deals in greater detail with a number of recent studies that illustrate the nature of ongoing activity in the field. Edited by one of the world's top researchers and featuring contributions from accomplished researchers, Bioorganic Chemistry is a state of the art, accessible account of the subject area which offers readers insights into the most current directions of research and important applications.Bioorganic Chemistry comprises three volumes: Nucleic Acids; Peptides and Proteins; and Carbohydrates.

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From Our Editors

Bioorganic Chemistry: Nucleic Acids, provides an overview of DNA and RNA, including coverage of biosynthesis, structure, and their functions in information storage and transmission. Special emphasis is given to the manner in which the individual chemistries of DNA and RNA conduce to their specific functions. The chemistry of molecules ...

From the Publisher

Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into the workings of biological systems at a molecular level. Recently, this growing field has witnessed some very exciting results inapplying design and synthesis techniques to many p...

From the Jacket

Bioorganic Chemistry: Nucleic Acids, provides an overview of DNA and RNA, including coverage of biosynthesis, structure, and their functions in information storage and transmission. Special emphasis is given to the manner in which the individual chemistries of DNA and RNA conduce to their specific functions. The chemistry of molecules ...

Sidney M. Hecht is at University of Virginia.

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Format:HardcoverDimensions:512 pages, 6.73 × 9.57 × 1.14 inPublished:September 1, 1993Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195084675

ISBN - 13:9780195084672

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Table of Contents

PrefaceList of Contributors1. Eric C. Long: Fundamentals of Nucleic Acids2. Serge L. Beaucage and Marvin H. Caruthers: The Chemical Synthesis of DNA/RNA3. Mark Van Cleve: Enzymatic Methods for the Preparation and Manipulation of Nucleic Acids4. M. Sriram and Andrew H.J. Wang: Structure of DNA and RNA5. Thomas D. Tullius: Chemical Mapping of Nucleic Acid Conformation6. Kenneth J. Addess and Juli Feigon: Introduction to H NMR Spectroscopy of DNA7. David M. J. Lilley: The Formation of Alternative Structures in DNA8. Maryanne J. O'Donnell and Larry W. McLaughlin: Reporter Groups for the Analysis of Nucleic Acid Structure9. Sergei A. Kazakov: Nucleic Acid Binding and Catalysis by Metal Ions10. John A. Mountzouris and Laurence H. Hurley: Small Molecule-DNA Interaction11. Christopher J. Larson and Gregory L. Verdine: The Chemistry of Protein-DNA Interactions12. Paul S. Miller: Antisense/Antigene Oligonucleotides13. Francis J. Schmidt: Catalytic RNA14. Reuel B. Van Atta and Sam J. Rose: The Polymerase Chain Reaction and In Vitro Random SelectionReferencesIndex

From Our Editors

Bioorganic Chemistry: Nucleic Acids, provides an overview of DNA and RNA, including coverage of biosynthesis, structure, and their functions in information storage and transmission. Special emphasis is given to the manner in which the individual chemistries of DNA and RNA conduce to their specific functions. The chemistry of molecules that disrupt nucleic acid biosynthesis and functions, antisense technologies involving RNA and DNA, and naturally occurring ribozymes are also covered. Each chapter begins with an introduction that includes basic principles, a summary of key findings which support current research in the field, and an overview of current research activity. The remainder of each chapter deals in greater detail with a number of recent studies that illustrate the nature of ongoing activity in the field. All chapters have been written by leading researchers, and numerous references are given.

Editorial Reviews

"...the editor and his contribuators have succeeded admirably in producing a modestly priced book that will be very useful, not only for its target audience of students but for anyone wishing to have a concise yet thorough overview of the field."--Manfred E. Wolff, Journal of MedicinalChemistry