Bioorganic Chemistry: Peptides and Proteins: Peptides and Proteins

Hardcover | February 1, 1998

EditorSidney M. Hecht

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Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into the workings of biological systems at a molecular level. Recently, this growing field has witnessed some very exciting results inapplying design and synthesis techniques to many problems in molecular biology. Bridging the gap between chemistry and biology, Topics in Bioorganic and Biological Chemistry: A Series of Books in Support of Teaching and Research will serve the needs of the many graduate students and researchers whowork in and study this discipline. This second volume, Bioorganic Chemistry: Peptides and Proteins, provides a broad overview of the topic. It covers the chemical synthesis of peptides and proteins and modern methods for analysis of protein structure and folding, reviews the ways in which proteins function as catalysts, andcompares enzymes with antibody catalysts. The text is comprised of 14 chapters, making it ideal for use in a one-semester, graduate level special topic course in peptides and proteins. Each chapter begins with an introduction that includes basic principles, a summary of key findings which support current research in the field, and an overview of current research activity. The remainder of each chapter deals in greater detail with a number of recent studies that illustrate thenature of ongoing activity in the field. All chapters have been written by leading researchers, and numerous references are given. Topics in Bioorganic and Biological Chemistry is the first series specifically designed to facilitate the education of graduate students and postdoctoral researchers.The first three volumes in the series, Bioorganic Chemistry: Nucleic Acids, Peptides and Proteins, and Carbohydrates, will also prove helpful to research workers who wish to gain familiarity with specific research topics.

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Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into the workings of biological systems at a molecular level. Recently, this growing field has witnessed some very exciting results inapplying design and synthesis techniques to many p...

Sidney M. Hecht is at University of Virginia.

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Format:HardcoverDimensions:544 pages, 6.69 × 9.09 × 1.18 inPublished:February 1, 1998Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195084683

ISBN - 13:9780195084689

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Table of Contents

PrefaceContributors1. Milton J. Axley: Introduction to Peptides and Proteins2. Victor Hruby and Jean-Philippe Meyer: Chemical Synthesis of Peptides3. Michael C. Fitzgerald and Stephen B.H. Kent: Total Chemical Synthesis of Proteins4. John E. Shively: Structural Analysis of Proteins5. Charles W. Carter. Jr.: Protein Structure6. Zhi-Ping Liu, Josep Rizo, and Lila M. Gierasch: Protein Folding7. Michael A. Massiah, Paul R. Blake, and Michael F. Summers: Nucleic Acid Interactive Protein Domains That Require Zinc8. John A. Gerlt: Understanding the Mechanisms and Rates of Enzyme-Catalyzed Proton Transfer Reactions to and from Carbon9. Paul J. Loida, Ronald A. Hernan, and Stephen G. Sligar: Site-Directed Mutagenesis10. Donald Hilvert, Gavin MacBeath, and Jumi A. Shin: The Structural Basis of Antibody Catalysis11. Arno F. Spatola: Peptide Hormones12. Hiroshi Nakanishi and Michael Kahn: Peptide Mimetics13. Zhen Yang and Alan J. Russell: Use of Enzymes in Organic Synthesis14. David A. Tirrell, Jane G. Tirrell, Thomas L. Mason, and Maurille J. Fournier: Engineered Proteins in Materials ResearchReferencesIndex