Biophysics of Computation: Information Processing in Single Neurons

Paperback | January 20, 2005

byChristof Koch

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Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neuronschallenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and howinformation can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes. Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritictrees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium- and potassium-currents and their role in information processing; the role of diffusion, buffering and binding of calcium,and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation. Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical andcomputer engineering, and physics.

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Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neuronschallenges this notion, using richly detailed ex...

Christof Koch is at California Institute of Technology.

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Format:PaperbackDimensions:588 pages, 6.42 × 9.21 × 1.1 inPublished:January 20, 2005Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195181999

ISBN - 13:9780195181999

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Table of Contents

1. The Membrane Equation2. Linear Cable Theory3. Passive Dendritic Trees4. Synaptic Input5. Synaptic Interactions in a Passive Dendritic Tree6. The Hodgkin-Huxley Model of Action-Potential Generation7. Phase Space Analysis of Neuronal Excitability8. Ionic Channels9. Beyond Hodgkin and Huxley: Calcium, and Calcium-Dependent Potassium Currents10. Linearizing Voltage-Dependent Currents11. Diffusion, Buffering, and Binding12. Dendritic Spines13. Synaptic Plasticity14. Simplified Models of Individual Neurons15. Stochastic Models of Single Cells16. Bursting Cells17. Input Resistance, Time Constants, and Spike Initiation18. Synaptic Input to a Passive Tree19. Voltage-Dependent Events in the Dendritic Tree20. Unconventional Coupling21. Computing with Neurons -- A Summary