Biotechnology and Safety Assessment

Other | September 1, 2002

byThomas, John A., John A. Thomas

not yet rated|write a review

A comprehensive treatise on new developments in biotechnology, the authors of Biotechnology and Safety Assessment, 3e, bring readers an up-to-date review of food safety issues, pre-clinical safety and development of new foods and drugs, plant biotechnology, food allergies and safety assessment, and consumer benefits with regard to genetically modified food.

Tomorrow's foods will be obtained from genetically modified crops, offering consumers higher nutritional value and more of it. Our medications will be obtained through a variety of biotechnological procedures yielding more potent and specific medications for diseases and vaccines. In order to make this view of the future come to light, John A. Thomas and Roy L. Fuchs have updated their classic in order to keep readers one step ahead.

Written by internationally recognized molecular biologists, plant agronomists, microbiologists, toxicologists, nutritionists, and regulatory authorities, this third edition is an excellent and authoritative resource, making it a valuable resource to any biomedical library or scientific bookshelf.

  • Provides timely coverage on topics of agribiotechnology and biotherapeutics
  • Describes the recent progress in genetically modified crops and their safety
  • Presents an update of the newer developments in therapeutic agents
  • Discusses role of genetically modified microorganisms in the development of new food products
  • Outlines various global regulatory issues relating to GM crops
  • Addresses environmental and ecological topics related to GM crops

Pricing and Purchase Info

$171.79 online
$223.10 list price (save 22%)
In stock online
Ships free on orders over $25

From the Publisher

A comprehensive treatise on new developments in biotechnology, the authors of Biotechnology and Safety Assessment, 3e, bring readers an up-to-date review of food safety issues, pre-clinical safety and development of new foods and drugs, plant biotechnology, food allergies and safety assessment, and consumer benefits with regard to gene...

Format:OtherDimensions:400 pages, 1 × 1 × 1 inPublished:September 1, 2002Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:008052818X

ISBN - 13:9780080528182

Customer Reviews of Biotechnology and Safety Assessment


Extra Content

Table of Contents



Chapter 1. Using Plant Biotechnology to Reduce Allergens in Food: Status and Future Potential


Characteristics of Food Allergens

Traditional Plant Breeding Methods for Reducing Allergenicity

Use of Genetic Engineering to Reduce Allergenic Potential

Concluding Remarks


Chapter 2. Experience with Biosafety Research and Postmarket Environmental Monitoring in Risk Management of Crops Derived from Plant Biotechnology


End Points and Definitions

Regulatory Aspects

Biosafety Research on Virus-Resistant Sugar Beet

Using Biogeographical Data for Biosafety Research

Monitoring of Insect-Resistant Maize

Concluding Remarks: Linking Biosafety Research and Monitoring


Chapter 3. Safety Assessment of Foods and Food Ingredients Produced by Genetically Modified Microorganisms


Issues in Food and Food Ingredients Produced From rDNA

Concepts in Safety Testing

Regulatory Requirements

Case Studies in Safety Assessment

Concluding Remarks


Chapter 4. Food Safety Assessment of Current and Future Plant Biotechnology Products


Safety Evaluation and the Substantial Equivalence Paradigm

How are Genetically Modified Foods Evaluated for Food Safety?

Future Trends in Food Safety Assessments

Concluding Remarks and Future Prospects


Chapter 5. Plant Biotechnology Products with Direct Consumer Benefits


Improved Nutritional Qualities

Products with Enhanced Quality Traits

Concluding Remarks


Chapter 6. Animal Feeds from Crops Derived through Biotechnology: Farm Animal Performance and Safety


Crops Fed to Farm Animals in the United States

Characteristics of Intake and Digestion by Farm Animals

Performance, Health, and Nutrient Utilization for Farm Animals Consuming Biotechnology-Derived Crops

Composition of Meat, Milk, and Eggs from Farm Animals Consuming Biotechnology-Derived Crops

Detecting Plant Source Proteins and DNA in Animal Products

Concluding Remarks: Future Directions


Chapter 7. Preclinical Immunotoxicology Assessment of Cytokine Therapeutics


Cytokines and Their Role in Health and Disease

Modulation of Cytokine Activity as a Therapeutic Modality

Clinical Toxicity Associated with Modulation of Cytokine Activity

Immunotoxicolcogy Assessment of Cytokine Therapeutics

Concluding Remarks


Chapter 8. Ecological Assessment of Crops Derived through Biotechnology



Ecological Risk Assessment Principles

Ecological Risk Assessment Principles for Genetically Modified Plants

Concluding Remarks


Chapter 9. Ribozyme Technology and Drug Development


Nonenzymatic Antisense Oligonucleotides as Inhibitors of Specific Gene Expression

RNA-based Enzymes

Catalytic DNAs

Therapeutic Applications of Catalytic Oligonucleotides

Ribozyme Delivery, Pharmacokinetics, and Metabolism

Concluding Remarks: Future Prospects


Chapter 10. Biotherapeutics: Current Status and Future Directions


Recombinant Proteins: Approved for Clinical Use

Interferon Alfa

Recombinant Proteins in Clinical Development

Natural Biological Response Modifiers

Chemically Defined Biological Response Modifiers

Combination Chemotherapy, Immunotherapy, and Cellular Therapy

Concluding Remarks


Chapter 11. Food Allergy Assessment for Products Derived through Plant Biotechnology

Introduction to Food Allergies and Allergens

Novel Proteins: Justification for Allergenicity Assessment

Allergy Assessment in the Gene Discovery Phase

Decision Tree Approach: The 2001 FAO/WHO Decision Tree

Example Applications of Allergenicity Assessment

Concluding Remarks


Chapter 12. Biotechnology: Safety Evaluation of Biotherapeutics and Agribiotechnology Products




Concluding Remarks


Chapter 13. The Potential of Plant Biotechnology for Developing Countries


Agriculture in Africa

African Crops and their Problems

Vaccines for Africa

Genetically Modified Crops in South Africa

Genetically Modified Crops in Developing Countries

The Anti-GMO Lobby and Developing Countries

Future Directions

Concluding Remarks


Chapter 14. Preclinical Safety Evaluation of Vaccines


Regulatory Framework

Outline of the Proposed Studies

Concluding Remarks


Chapter 15. Gene Flow from Transgenic Plants


Initial Hybrid Formation

Transgene Introgression

Transgene Spread

Concluding Remarks


Chapter 16. Safety Assessment of Insect-Protected Cotton


Molecular Characterization of Bollgard Cotton

Cry1Ac and NPT II Protein Levels in Bollgard Cotton Plants

Safety Assessment of the Cry1Ac and NPT II Proteins in Bollgard Cotton

Compositional Analysis and Nutritional Assessment of Bollgard Cotton

Horizontal Gene Transfer and the Assessment of Marker Genes

Environmental Assessment

Concluding Remarks