Bone Cancer: Progression and Therapeutic Approaches by Dominique HeymannBone Cancer: Progression and Therapeutic Approaches by Dominique Heymann

Bone Cancer: Progression and Therapeutic Approaches

byDominique Heymann, Dominique Heymann

Other | August 20, 2009

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The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.

Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality.

Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.

  • Feature

  • Presents a comprehensive, translational source for all aspects of bone cancer in one reference work

  • Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches.

  • Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems

  • Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches

  • Benefit

  • Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles.

  • Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system

  • Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit

  • Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Dominique Heymann studied cell biology, biochemistry and immunology in INSERM (French NIH) unit 211 at the University of Nantes and received his Ph.D. in 1995. He was appointed Associate Professor in 2001 in the Department of Histology and Embryology. In 2009, he was awarded a personal Chair of Histology and Embryology.Currently he is ...
Title:Bone Cancer: Progression and Therapeutic ApproachesFormat:OtherDimensions:504 pages, 1 × 1 × 1 inPublished:August 20, 2009Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080953883

ISBN - 13:9780080953885


Table of Contents

Section 1: Introduction

Genetic control, frequencies and epidemiology of bone cancers

The incidence and progression of metastatic bone lesions

Section 2: Bone microenvironment and bone cancer

Bone microenvironment and tumor growth

Osteoblast Differentiation and Cell Signalling

Osteoclast Differentiation and Function

Cytokines in bone remodeling and bone tumors

Proteases and bone tumors - therapeutic approaches

Section 3: Bone markers

Early bone metastasis

Bone remodeling markers and bone cancer

Proteomic of bone cancers

Genomic Alterations in Bone Tumors

Biology of bone tumors and new diagnostic tools

Gene profiling of osteosarcoma

Molecular pathology of osteosarcoma

Histopathology of prostate and breast metastases

Technical aspects: how do we best prepare bone samples for proper histological analysis?

Section 4: Myeloma, odontogenic tumors and bone metastases

Multiple myeloma bone diseases

Osteolytic lesions

Bone metastases of prostatic cancer

Bone metastases of breast cancer

Section 5: Primary bone tumors

Osteosarcoma and osteoblasts: diagnosis and therapy

Ewing sarcoma family of tumors: diagnosis and therapy

Non-surgical treatment of chondrosarcoma: diagnosis and therapy

Chondrosarcoma of bone: diagnosis and therapy

Osteoclast-rich lesions of bone: diagnosis and therapy

Section 6: Imaging of bone cancers

Interventional Radiologic Techniques

Imaging of bone metastases

Diagnosis of bone metastases

Section 7: Pain control in bone cancers

Pain control with radiotherapy

Mechanisms and management of bone cancer pain

Malignant skeletal pain

Section 8: New therapeutic advances of bone cancers

Primary bone tumors and novel therapeutic approaches

Cytokine gene therapy in bone remodeling


Multi-targeted approach

RANKL and targeted therapy

Apoptosis and drug resistance