Brain Damage, Brain Repair

Paperback | October 15, 2002

byJames W. Fawcett, Anne E. Rosser, Stephen B. Dunnett

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Now available in paperback.Many neurological conditions are caused by damage to neurons and glial cells. For most of these diseases there are at present no effective treatments to minimise the extent of neuronal and glial loss, and no effective way of replacing what has been lost. This picture is rapidly changing. Developments in basic neuroscience have produced various potential therapies that can protect neurons and glia followiing traumatic, anoxic, infectious and immunological damage. The old doctrine that axons cannot be made to regenerate, and dead neurons cannot bereplaced is no longer tenable, and a wide variety of reconstructive techniques for the nervous system are under development. These and other basic science discoveries will progress into clinical practice, and lead to a revolution in neurology and neurosurgery. This book describes the variousconditions that lead to damage to the nervous system, and the ways in which they may be ameliorated. It covers the burgeoning science of reconstruction of the nervous system, through neuronal, glial and stem cell transplantation, axon regeneration, remyelination, plasticity and pharmacologicalinterventions. The clinical conditions to which these treatments will be applied and their assessment are described.This is the first book to cover this enormous and expanding field of neuroscience and neurology. It will be useful to students and scientists working in the field of nervous system damage and reconstruction, and also to clinicians who wish to look forward to the developments which will shape thefuture of their practice.

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Now available in paperback.Many neurological conditions are caused by damage to neurons and glial cells. For most of these diseases there are at present no effective treatments to minimise the extent of neuronal and glial loss, and no effective way of replacing what has been lost. This picture is rapidly changing. Developments in bas...

James W. Fawcett is in the Department of Physiology, University of Cambridge. Anne E. Rosser and Stephen B. Dunnett are both at the School of Biosciences, Cardiff University.

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Format:PaperbackDimensions:484 pages, 9.53 × 7.09 × 0.99 inPublished:October 15, 2002Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198523378

ISBN - 13:9780198523376

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Table of Contents

Section I: Mechanisms of Brain Damage1. Death and survival in the nervous system2. Axotomy and mechanical damage3. Metabolic damage4. Inflammation and demyelination (with Neil Scolding)5. Infection (with Roger Barker)6. Neurodegenerative disease (with Harry Baker)Section II: Damage Limitation7. Neuroprotection8. Joe Herbert: Steroids9. Growth factors10. Control of inflammationSection III: Intrinsic mechanisms of recovery11. Peripheral nerve regeneration12. Failure of CNS regeneration13. Anatomical plasticity14. Biochemical plasticity15. Robin Franklin: RemyelinationSection IV: Clinical Assessment of Brain Damage16. Coma (with Barbara Wilson)17. Motor, sensory and autonomic failure (with Charlotte Behan)18. Cognition (with Andrew Lawrence and B J Sahakian)19. Neuropsychiatry (with German Berrios and Eugene Paykel)Section V: Pharmacology and Rehabilitation20. Pharmacological management (with Roger Barker)21. Ian Robertson and Barbara Wilson: Neuropsychological rehabilitationSection VI: Structural Repair22. Axon regeneration in the CNS23. Primary neuronal grafts24. Robin Franklin: Glial grafts25. Stem cells26. Gene therapy (with Stacey Efsthathiou)Appendix - specific diseases