Brain Development in Drosophila melanogaster

Hardcover | March 28, 2008

EditorGerhard Martin Technau

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The central nervous system (CNS) represents the organ with the highest structural and functional complexity. Accordingly, uncovering the mechanisms leading to cell diversity, patterning and connectivity in the CNS is one of the major challenges in developmental biology. The developing CNS of the fruitfly Drosophila melanogaster is an ideal model system to study these processes. Several principle questions regarding neurogenesis (like stem cell formation, cell fate specification, axonal pathfinding) have been addressed in Drosophila by focusing on the relatively simply structured truncal parts of the nervous system. However, information processing (e.g., vision, olfaction), behavior, learning and memory require highly specialized structures, which are located in the brain. Owing to much higher complexity and hidden segmental organisation our understanding of brain development is still quite rudimentary. Considerable advances have been made recently in bringing the resolution of brain structures to the level of individual cells and their lineages, which significantly facilitates investigations into the mechanisms controlling brain development. This book provides an overview of some major facets of recent research on Drosophila brain development.

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The central nervous system (CNS) represents the organ with the highest structural and functional complexity. Accordingly, uncovering the mechanisms leading to cell diversity, patterning and connectivity in the CNS is one of the major challenges in developmental biology. The developing CNS of the fruitfly Drosophila melanogaster is an i...

Format:HardcoverDimensions:174 pages, 10 × 7.01 × 0.27 inPublished:March 28, 2008Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387782605

ISBN - 13:9780387782607

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Table of Contents

CONTENTS1. The Development of the Drosophila Larval BrainVolker Hartenstein, Shana Spindler, Wayne Pereanu and Siaumin FungAbstractSynopsis of the Phases and Elements of Drosophila Brain DevelopmentProgenitors of the Drosophila Brain: Neuroblasts and Ganglion Mother CellsThe Generic Cell Types of the Drosophila BrainNeuroanatomy of the Developing Drosophila Brain: The Systems of Lineages,Tracts and CompartmentsOutlook2. Anteroposterior Regionalization of the Brain: Genetic and Comparative AspectsRobert Lichtneckert and Heinrich ReichertAbstractIntroductionThe Cephalic Gap Genes Otd/Otx and Ems/Emx Control AnteriorBrain DevelopmentThe Hox Genes Pattern the Posterior BrainEvidence for a Tripartite Organization of the Brain3. Dorsoventral Paterning of the Brain: A Comparative ApproachRolf Urbach and Gerhard M. TechnauAbstractIntroductionDV Patterning of the Truncal Part of the CNS in Drosophila and vertebratesDV patterning of the brain in DrosophilaA comparison with DV regionalization of the vertebrate telencephalonConclusions4. Disection of the Embryonic Brain Using Photoactivated Gene ExpresionJonathan MindenAbstractIntroductionProcephalic Blastoderm Fate MapBrain-Forming Mitotic Domains Populate Distinct Brain RegionsConclusion5. Design of the Larval Chemosensory SystemReinhard F. StockerAbstractIntroductionChemosensory Organs of the Larval HeadOlfactory SystemGustatory SystemThe Drosophila Larva as a Model for Smell and Taste6. Development of the Drosophila Olfactory SystemVeronica Rodrigues and Thomas HummelAbstractIntroductionOrganization of the Drosophila Adult Olfactory SystemSpecification of the Olfactory Sense OrgansOlfactory Lineages RevisitedOrigin of Glial CellsDevelopment of ORN ConnectivityOlfactory Map OrganizationCellular and Molecular Mechanisms of ORN Wiring SpecificitySpecification of Projection NeuronsDevelopment of PN DendritesConcluding Remarks7. The Olfactory Sensory Map in DrosophilaPhilippe P. Laissue and Leslie B. VosshallAbstractIntroductionOlfactory Organs and Olfactory Sensory Neurons of DrosophilaOdorant Receptor Gene ExpressionLigand Tuning ProfilesA Receptor-Based Map of Glomerular ProjectionsSexual Dimorphism in the Drosophila Olfactory SystemConcluding Remarks8. Optic Lobe DevelopmentKarl-Friedrich Fischbach and Peter Robin HiesingerAbstractIntroductionThe Adult Visual System Is Organized into Parallel VisuotopticFunctional PathwaysLamina DevelopmentMedulla and Lobula Complex DevelopmentConcluding Remarks9. Clonal Unit Architecture of the Adult Fly BrainKei Ito and Takeshi AwasakiAbstractIntroductionStructure of the Adult BrainTechniques for Visualising Clonally Related ProgenyClonal Unit Architecture in the Adult BrainFormation of the Clonal Units During DevelopmentFunctional Importance of the Clonal UnitsConclusionINDEX