Brain Tumors by Francis Ali-OsmanBrain Tumors by Francis Ali-Osman

Brain Tumors

EditorFrancis Ali-Osman

Paperback | December 8, 2010

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A comprehensive guide for both scientists and clinicians to recent advances in our understanding of the cellular and molecular processes involved in the initiation, progression, and clinical and biological behavior of brain tumors. The authors review the latest findings on the molecular biology, genetics, epidemiology, and pathology of brain tumors, detailing new knowledge about molecular profiling, molecular pathology and classification, in vitro and in vivo brain tumor models, brain metastasis, and progenitor cell biology. They also discuss in depth the cellular and genetic pathways involved in brain oncogenesis, malignant progression, and therapeutic response, highlighting oncogenes and tumor suppressor genes, DNA damage and repair, invasion and migration, cell cycle, growth factors, signaling, apoptosis, and developmental biology. The discussion of brain tumor therapy focuses on advances in pharmacological thinking, therapeutic modalities, novel therapeutic targets, rational drug design, gene and viral therapies, drug delivery and the blood-brain barrier, immunotherapy, and brain imaging.
Title:Brain TumorsFormat:PaperbackDimensions:406 pagesPublished:December 8, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617373206

ISBN - 13:9781617373206

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Table of Contents

Part I: Epidemiology, Biology, Genetics, and PathologyEpidemiology of Brain TumorsRanda El-Zein, Melissa Bondy, and Margaret WrenschMolecular Genetics of Tumors of the Central Nervous SystemC. David JamesMolecular Pathology of Nervous System TumorsCatherine L. Nutt, Anat O. Stemmer-Rachamimov, J. Gregory Cairncross, and David N. LouisGenetic Modeling of Glioma Formation in MiceMartin Begemann, Vinagolu K. Rajasekhar, Gregory N. Fuller, and Eric C. HollandBiology of Brain MetastasisMinsoo Kang, Takamitsu Fujimaki, Seiji Yano, and Isaiah J. FidlerAnalysis of Neural Precursor Cells in the Context of Origin of Brain Tumors, Their Treatment, and Repair of Treatment-Associated DamageMark Noble and Joerg DietrichBiology of Primitive Neuroectodermal TumorsJohn R. Hill, Shoichiro Ohta, and Mark A. IsraelPart II: Mechanisms and PathwaysMolecular and Cellular Biology of the Blood-Brain Barrier and Its Characteristics in Brain TumorsHelga E. de Vries, Lisette Montagne, Christine D. Dijkstra, and Paul van der ValkImmune Regulation in the Brain: Lessons From Autoimmunity and Implications for Brain Tumor TherapyLois A. LampsonGenetic Pathways in the Evolution of GliomasHiroko Ohgaki and Paul KleihuesDNA Damage and Repair in the Therapeutic Response of Tumors of the Central Nervous SystemHenry S. Friedman, M. Eileen Dolan, and Francis Ali-OsmanRole of Urokinase-Type Plasminogen Activator Receptor in Human Glioma InvasionSanjeeva Mohanam and Jasti S. RaoRegulation of Cell Cycle and Apoptosis in Human Brain TumorsJuan Fueyo, Candelaria Gomez-Manzano, and Timothy J. McDonnellPart III: TherapeuticsSystemic Chemotherapy for Metastatic Tumors of the Central Nervous SystemCharles A. Conrad and W. K. Alfred Yung<_0a_radiation20_biology20_and20_therapy20_of20_tumors20_of20_the20_central20_nervous20_system0a_0a_nalin20_gupta2c_20_john20_r.20_fike2c_20_penny20_k.20_sneed2c_20_philip20_j.20_tofilon2c_20_and20_dennis20_f.20_deen0a_0a_0a_0a_advances20_in20_the20_management20_of20_cerebral20_metastases0a_0a_fadi20_hanbali20_and20_raymond20_sawaya0a_0a_0a_0a_immunotherapy20_of20_central20_nervous20_system20_tumors3a_20_contemporary20_cancer20_research0a_0a_amy20_b.20_heimberger2c_20_david20_a.20_reardon2c_20_darell20_d.20_bigner2c_20_and20_john20_h.20_sampson0a_0a_0a_0a_targeting20_drugs20_to20_tumors20_of20_the20_central20_nervous20_system0a_0a_maciej20_s.20_lesniak2c_20_james20_frazier2c_20_and20_henry20_brem0a_0a_0a_0a_rational20_design20_and20_development20_of20_targeted20_brain20_tumor20_therapeutics0a_0a_francis20_ali-osman2c_20_henry20_s.20_friedman2c_20_gamil20_r.20_antoun2c_20_david20_reardon2c_20_darell20_d.20_bigner2c_20_and20_john20_k.20_buolamwini0a_0a_0a_0a_index radiation="" biology="" and="" therapy="" of="" tumors="" the="" central="" nervous="" system="" nalin="" _gupta2c_="" john="" r.="" _fike2c_="" penny="" k.="" _sneed2c_="" philip="" j.="" _tofilon2c_="" dennis="" f.="" deen="" advances="" in="" management="" cerebral="" metastases="" fadi="" hanbali="" raymond="" sawaya="" immunotherapy="" _tumors3a_="" contemporary="" cancer="" research="" amy="" b.="" _heimberger2c_="" david="" a.="" _reardon2c_="" darell="" d.="" _bigner2c_="" h.="" sampson="" targeting="" drugs="" to="" maciej="" s.="" _lesniak2c_="" james="" _frazier2c_="" henry="" brem="" rational="" design="" development="" targeted="" brain="" tumor="" therapeutics="" francis="" _ali-osman2c_="" _friedman2c_="" gamil="" _antoun2c_="" buolamwini="">

Editorial Reviews

"This is an important book for the shelves of neuroscience, neurology, neurosurgery, and oncology departments. It's well worth the price." - Doody's Health Sciences Book Review Journal"This book contains a welcome compilation of the known genetic reference with a good description of each abnormality." - The New England Journal of Medicine"...this book is simply indispensable and should be a significant component for all individuals associated with either biology or treatment of gliomas...a thoroughly comprehensive, up-to-date, and timely review... ." - J. Neurosurg