Bursting Neurons And Fading Memories: An Alternative Hypothesis Of The Pathogenesis Of Alzheimer's…

Paperback | October 20, 2014

byMichael R. D'andreaEditorMichael R. D'andrea

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Advances in Alzheimer's disease AD research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals i.e., from Pfizer, Eli Lilly, etc. , and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

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From the Publisher

Advances in Alzheimer's disease AD research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inco...

From the Jacket

Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning (and sole) hypothesis suggests that AD is the result of extracellular amyloid deposition that seeds to form amyloid plaques, which then grow and kill neighboring neurons. However, the...

Dr. D Andrea has a PhD in Cell and Developmental Biology and an MS in Molecular Biology. He has authored over 100 scientific publications, including invited review papers on Alzheimer's disease, and co-invented 11 patents. His technical expertise is in the areas of histopathology/neuropathology, immunohistochemistry, and image analysis...

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Format:PaperbackDimensions:170 pages, 8.75 × 6.35 × 0.68 inPublished:October 20, 2014Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128019794

ISBN - 13:9780128019795

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Extra Content

Table of Contents

Introduction

1. Alzheimer's Disease Today

2. Seeds of a New Perspective

3. Introducing the "Inside-Out" Hypothesis

4. Addressing Technical Concerns

5. The Good Intentions of Formic Acid

6. Connecting MAP-2 and Cell Lysis

7. Classifying Plaques

8. When is a Star Like a Plaque?

9. The Inflammation Cascade

10. Innocent Aß42

11. The Alpha 7 Nicotinic Acetylcholine Receptor

12. Immunoglobulin: Another Perpetrator

13. Add AD to the List of Autoimmune Diseases

14. The BBB and BRB in AD

15. "Inside-Out" in the Field

16. Alzheimer's Disease Tomorrow

Glossary

Editorial Reviews

"In addition to presenting and supporting his specific hypothesis, the author succeeds in conveying a number of important points regarding scientific research in general and the IHC methods specifically."--Biotechnic & Histochemistry, Bursting Neurons and Fading Memories "The methodical approach described here, including the careful attention to possible sources of artifacts, is a realistic portrayal of the hard work required both in the laboratory and at the microscope."