C. elegans: Methods and Applications by Kevin StrangeC. elegans: Methods and Applications by Kevin Strange

C. elegans: Methods and Applications

EditorKevin Strange

Paperback | December 1, 2010

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Nonmammalian model organisms have become a cornerstone of systems biology research. Like the Rosetta Stone, which enabled modern scholars to decode ancient Egyptian hieroglyphics, model organisms enable biologists to decipher the genetic code underlying the complex physiological processes common to all life. C. elegans provides a particularly striking example of the experimental utility of model organisms. Genetic, molecular and systems biological characterization of this organism is greatly facilitated by its short life cycle and high rate reproduction, and by the ease with which it can be cultured in the laboratory. C. elegans also has a fully sequenced and well-annotated genome, which is assembled in readily accessible public databases along with virtually all other biological data on this organism. C. elegans: Methods and Applications aims to enhance the readily available methodologies for the study of C. elegans by providing overviews and concise, step-by-step descriptions of the most state-of-the-art methods currently being utilized in the field. Some of the methods presented include forward and reverse genetic analysis, data mining and comparative genomics strategies, electron and fluorescence microscopy methods, automated imaging methods for worm behavioral analysis, functional genomics strategies, and cutting-edge methods for physiological analyses. This comprehensive collection of methods, written by experts in the field, endeavors to serve as a roadmap for researchers, illustrating the type or research that is possible with C. elegans, and illuminating its potential as a vehicle for future discovery.
Title:C. elegans: Methods and ApplicationsFormat:PaperbackDimensions:304 pages, 9.02 × 5.98 × 0.01 inPublished:December 1, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:161737668X

ISBN - 13:9781617376689

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Table of Contents

An Overview of C. elegans BiologyKevin StrangeComparative Genomics in C. elegans, C. briggsae and Other Caenorhabditis SpeciesAvril Coghlan, Jason E. Stajich and Todd W. HarrisWormBase: Methods for Data Mining and Comparative GenomicsTodd W. Harris and Lincoln D. SteinC. elegans Deletion Mutant ScreeningRobert J. Barstead and Donald G. MoermanInsertional Mutagenesis in Caenorhabditis elegans Using the Drosophila Transposon Mos1: A Method for the Rapid Identification of Mutated GenesJean-Louis BessereauSNP MappingM. Wayne Davis and Marc HammarlundCreation of Transgenic Lines Using Microparticle Bombardment MethodsVida PraitisConstruction of Plasmids for RNAi and In Vitro Transcription of dsRNALisa TimmonsDelivery Methods for RNAi in Caenorhabditis elegansLisa TimmonsFunctional Genomic Approaches in C. elegansTodd LamitinaAssays for Toxicity Studies in C. elegans with Bt Crystal ProteinsLarry J. Bischof, Danielle L. Huffman and Raffi V. AroianFluorescent Reporter MethodsHarald HutterElectrophysiological Analysis of Neuronal and Muscle Function in C. elegansMichael M. Francis and Andres Villu MaricqSperm and Oocyte Isolation Methods for Biochemical and Proteomic AnalysisMichael A. MillerPreservation of C. elegans Tissue via High-Pressure Freezing and Freeze-Substitution for Ultrastructural Analysis and Immuno-CytochemistryRobby M. WeimerIntracellular pH Measurements In Vivo Using Green Fluorescent Protein VariantsKeith NehrkeAutomated Imaging of C. elegans BehaviorChristopher J. Cronin, Zhaoyang Feng and William R. SchaferIntracellular Ca2+ Imaging in Caehorhabditis elegansRex A. Kerr and William R. SchaferIn Vitro Culture of C. elegans Somatic Cells<_0a_kevin20_strange20_and20_rebecca20_morrison0a_0a_0a_0a_techniques20_for20_analysis2c_20_sorting2c_20_and20_dispensing20_of20_c.20_elegans20_on20_the20_copas20_flow20_sorting20_system0a_0a_rock20_pulak20_et20_al. kevin="" strange="" and="" rebecca="" morrison="" techniques="" for="" _analysis2c_="" _sorting2c_="" dispensing="" of="" c.="" elegans="" on="" the="" copas="" flow="" sorting="" system="" rock="" pulak="" et="">