Cancer biotherapy: An introductory guide

Paperback | May 4, 2006

EditorAnnie Young, Lewis Rowett, David Kerr

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Recent advances in biology and immunology have opened up new horizons in both our understanding of cancer as a disease, and the potential for cancer therapy. These major developments mean that chemotherapy, radiotherapy and surgery are no longer the only options. Biotherapy, or biologicaltherapy, is now regarded as the fourth treatment modality for patients with cancer. It utilises the great increase in our knowledge of molecular biology, cell biology and immunology to achieve tumour control. New biological agents are currently being used to treat cancer, such as monoclonal antibodies and vaccine therapies to stimulate the body's immune system to attack cancer cells. Biotherapy may be targeted to act specifically on cancer cells. Drugs such as monoclonal antibodies can be designed torecognize and find a particular type of cancer cell, attach itself to them, and destroy them. Naturally occuring biological molecules such as cytokines are also used, and the manipulation of normal biological mechanisms to control or inhibit tumour growth is another key feature of biotherapy. Edited by a team with perspectives in pharmacology, oncology and nursing, and with contributions from experts in the various areas of biotherapy, this book serves as an introduction to the subject. It includes the principles behind biological therapy, with discussion of the impact on the future ofthe fight against cancer. It has a strong clinical focus, describing the relevant biology and immunology while highlighting clinical relevance and treatment issues.

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Recent advances in biology and immunology have opened up new horizons in both our understanding of cancer as a disease, and the potential for cancer therapy. These major developments mean that chemotherapy, radiotherapy and surgery are no longer the only options. Biotherapy, or biologicaltherapy, is now regarded as the fourth treatme...

David Kerr is Rhodes Professor of Therapeutics and Clinical Pharmacology at the University of Oxford, and Director of the National Translational Cancer Research Network. He is Editor-in-Chief of OUP's journal Annals of Oncology, and is currently working in Oxford to build a new Institute for Cancer Medicine. He was awarded the CBE i...

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Format:PaperbackDimensions:336 pages, 9.21 × 6.14 × 0.76 inPublished:May 4, 2006Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:019856631X

ISBN - 13:9780198566311

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Table of Contents

David Kerr, Lewis Rowett and Annie Young: Introduction1. Lewis Rowett and Annie Young: An introduction to the cell biology of cancer2. Rachel Midgley: An introduction to the immune system and cancer3. David Kerr: The clinical development of biologic therapies4. Stefan Sleijfer, Kees Nooter and Jaap Verwejj: Kinase inhibitors5. Monica M Mita and Eric K Rowinsky: The RAS pathway - a target for anticancer therapy6. Manish A Shah, Archie Tse and Gary K Schwartz: The development of cell cycle active agents for cancer therapy7. Peter Borchmann and Andreas Engert: Therapeutic monoclonal antibodies8. Surinder K Sharma, Kenneth D Bagshawe and Richard H J Begent: Antibody Directed Enzyme Prodrug Therapy (ADEPT)9. Carla M L van Herpen and Cornelius J A Punt: Cytokines10. Dirk Laurent: Inhibitors of invasion and angiogenesis11. Aniruddha Choudhury and Hakan Mellstedt: Proteins, peptides and DNA vaccines for cancer12. Neil Steven: Cell based immunotherapy13. Deborah Beirne and Leonard Seymour: Gene therapy for cancer - approaches and ethical considerations14. Wan-Teck Lim and Howard L McLeod: Individualising cancer therapyGlossary