Cancer Chemoprevention: Volume 1: Promising Cancer Chemopreventive Agents by Gary J. KelloffCancer Chemoprevention: Volume 1: Promising Cancer Chemopreventive Agents by Gary J. Kelloff

Cancer Chemoprevention: Volume 1: Promising Cancer Chemopreventive Agents

byGary J. KelloffEditorErnest T. Hawk, Caroline C. Sigman

Paperback | November 19, 2010

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A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.
Title:Cancer Chemoprevention: Volume 1: Promising Cancer Chemopreventive AgentsFormat:PaperbackDimensions:697 pagesPublished:November 19, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617373427

ISBN - 13:9781617373428

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Table of Contents

Part I. AntimutagensInducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and SulforaphaneThomas W. Kensler and Paul TalalayChemoprevention by IsothiocyanatesStephen S. HechtAntigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-CysteineSilvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D'Agostini, Maria Bagnasco, and Roumen BalanskyModifiers of Cytochrome(s) P450John DiGiovanni and Heather E. KleinerPart II. AntiinflammatoriesAntiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid MetabolismGary B. Gordon, Gary J. Kelloff, and Caroline C. SigmanCyclooxygenase-2 Inhibitors and Colorectal Cancer PreventionRaymond N. DuBoisLipoxygenases as Targets for Cancer PreventionSusan M. Fischer and Russell D. KleinInducible Nitric Oxide Synthase as a Target for ChemopreventionLorne J. Hofseth, Tomohiro Sawa, S. Perwez Hussain, and Curtis C. HarrisChemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-FluorouracilTimothy S. Wiedmann and Lee W. WattenbergChemoprevention of Cancer by CurcuminBandaru S. Reddy and Chinthalapally V. RaoProstacyclin and Lung Cancer ChemopreventionRobert L. Keith, York E. Miller, Paul A. Bunn Jr., Patrick Nana-Sinkam, Raphael A. Nemenoff, and Mark W. GeraciPart III. Nuclear Receptor SuperfamilyNuclear Receptor Superfamily: Targets for ChemopreventionJulia A. Lawrence and Kapil DhingraA. AntiandrogensProstate Cancer Chemoprevention: 5a-Reductase InhibitorsJennifer E. Drisko and Siu-Long YaoSearching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate CancerMark S. Chapman, William Y. Chang, Andrés Negro-Vilar, and Jeffrey N. MinerB. AntiestrogensAromatase Inhibitors as Chemopreventives of Breast CancerMitchell Dowsett and Judy E. GarberBreast Cancer Chemoprevention by Selective Estrogen Receptor ModulatorsCarolyn L. SmithC. Natural Vitamin D and Synthetic AnalogsChemopreventive Efficacy of Natural Vitamin D and Synthetic AnalogsKathryn Z. Guyton, Thomas W. Kensler, and Gary H. PosnerD. RetinoidsThe Retinoids and Cancer ChemopreventionSutisak Kitareewan, Ian Pitha-Rowe, Yan Ma, Sarah J. Freemantle, and Ethan DmitrovskyE. Dehydroepiandrosterone and Structural AnalogsBiologic and Therapeutic Effects of Dehydroepiandrosterone and Structural AnalogsArthur G. Schwartz and Laura L. PashkoPart IV. Signal Transduction Modulatorsras Oncogene InhibitorsNancy E. KohlThe Potential of EGFR-Targeted Agents in Cancer PreventionSteven D. Averbuch and Fadlo R. KhuriPharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone InhibitorsPaul WorkmanTherapeutic Strategies Targeting PolyaminesDebora L. Kramer and Eugene W. GernerThe Role of Phytoestrogens as Cancer Prevention AgentsStephen Barnes and Coral A. LamartiniereCancer Chemopreventive Activity of Monoterpenes and Other IsoprenoidsPamela L. Crowell and Michael N. GouldDevelopment of an Inhibitor of raf KinaseFrank McCormickAbnormalities in Cell Cycle Control in Human Cancer and Their Relevance to ChemopreventionAlessandro Sgambato and I. Bernard WeinsteinSelect Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and ChemotherapyMelissa K. Reeder, Rifat Pamakcu, I. Bernard Weinstein, Kirk Hoffman, and W. Joseph ThompsonPart V. Antioxidants, Vitamins, and MineralsChemoprevention by Fruit Phenolic CompoundsGary D. Stoner and Bruce C. CastoTea Polyphenols as Cancer Chemopreventive AgentsVaqar M. Adhami, Farrukh Afaq, Nihal Ahmad, Yukihiko Hara, and Hasan MukhtarVitamin E as a Cancer Chemopreventive AgentHan-Yao Huang, Sonja Berndt, and Kathy J. HelzlsouerVitamin C as a Cancer Chemopreventive AgentJane Higdon and Balz FreiCarotenoidsSusan T. Mayne and Brenda CartmelLycopene, a Dietary Cancer Chemopreventive AgentAndreas I. Constantinou and Richard B. van BreemenNot All Chemopreventive Selenium Compounds are Created EqualKaram El-BayoumyCalciumJohn A. BaronFolate and Cancer ChemopreventionShumin M. Zhang and Walter C. WillettConjugated Linoleic Acid as a Tumor Preventive AgentDavid Kritchevsky and Michael W. ParizaChemopreventive Effects of Omega-3 Fatty AcidsJoanne R. Lupton and Robert S. ChapkinPart VI. Agents Targeting Biological Processes Important in CancerTumor Angiogenesis as a Target for Early Intervention and Cancer PreventionWilliam W. LiProteasome Inhibitors in Cancer TherapyJulian AdamsModulation of DNA Methylation for the Treatment and Prevention of CancerDavid S. SchrumpTargeting Histone Deacetylase as a Strategy for Cancer PreventionHo Jung Oh, Eun Joo Chung, Sunmin Lee, Andrea Loaiza-Perez, Edward A. Sausville, and Jane B. TrepelIndex

Editorial Reviews

"...a comprehensive review of seizures...a wealth of information." - British Journal of Anesthesiology"...a valuable addition to any library in a lboratory researching/developing oncology products..." - BTS Newsletter"...provides a comprehensive reference survey for basic researchers, pharmacologists and clinical oncologists...a must for everyone involved in chemoprevention research." - Annals of Oncology