Cancer Gene Therapy by David T. CurielCancer Gene Therapy by David T. Curiel

Cancer Gene Therapy

EditorDavid T. Curiel, Joanne T. Douglas

Paperback | November 9, 2010

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A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Title:Cancer Gene TherapyFormat:PaperbackDimensions:504 pagesPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617374253

ISBN - 13:9781617374258

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Table of Contents

Cancer Gene Therapy: Historical PerspectiveMalcolm K. BrennerThe Genetic Basis of CancerAkseli Hemminki and Kari HemminkiTumor Suppressor Gene Replacement for CancerJack A. Roth and Susan F. GrammerAntisense TechnologyRuiwen Zhang and Hui WangCancer Therapeutic Applications of Ribozymes and RNAiLisa Scherer and John J. Rossi.Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy: A Better Class of KillerAndrew Bateman, Vy Phan, Alan Melcher, Emmanouela Linardakis, Kevin Harrington, and Richard VileSuicide Gene TherapyCaroline J. Springer and Ion Niculescu-DuvazMolecular Chemotherapy ApproachesDaniel H. Palmer and David J. KerrGenetic Immunotherapy ApproachesDenise R. Shaw and Albert F. LoBuglioImmunotherapy of Cancer By Dendritic Cell-Targeted Gene TransferTanja D. de Gruijl, Herbert M. Pinedo, and Rik J. Scheper.Dendritic CellsWeiping Zou, Shuang Wei, and Tyler J. CurielPolynucleotide Immunization for Cancer TherapyTheresa V. StrongDevelopment of Oncolytic Replication-Competent Herpes Simplex Virus Vectors: The G207 ParadigmTomoki Todo and Samuel D. RabkinDevelopment of Oncolytic Adenoviruses: From the Lab Bench to the BedsideJohn A. Howe, Robert Ralston, and Murali RamachandraConditionally Replicating Adenoviruses for Cancer TreatmentRamon AlemanyReovirus as an Oncolytic AgentMegan K. Patrick, Kara L. Norman, and Patrick W. K. LeeAntiangiogenic Gene Therapy of CancerSteve Gyorffy, Jack Gauldie, A. Keith Stewart, and Xiao-Yan WenProapoptotic Strategy in Cancer Gene TherapyDavid H. Holman, Marc L. Hyer, Ahmed El-Zawahry, Gina M. Keller, and James S. NorrisAntimetastasisDuen-Hwa Yan, Kung-Ming Rau, and Mien-Chie HungAntimetastatic Gene Therapy: Prostate Cancer Theory to TherapyThomas A. Gardner, Juan Antonio Jiménez, Leland W. K. Chung, and Chinghai KaoDrug Resistance Gene Transfer as an Antitumor StrategyColin L. Sweeney and R. Scott McIvorChemosensitizationPer Eystein LønningRadiosensitization by Gene TherapySteven J. Chmura, Michael Garofalo, and Ralph R. WeichselbaumNonviral Vector Systems for Cancer Gene TherapyGreg F. Walker and Ernst WagnerViral Vectors for Cancer Gene TherapyJoanne T. Douglas and David T. CurielBacterial Systems for Tumor-Specific Gene TherapyJ. Martin Brown, Shie-Chau Liu, Jan Theys, and Philippe LambinMolecular Imaging of Cancer Gene TherapyHarvey R. HerschmanCancer-Related Gene Therapy Clinical TrialsRobert J. Korst and Ronald G. CrystalRegulatory Aspects in the Development of Gene TherapiesRosemarie Aurigemma, Joseph E. Tomaszewski, Sheryl Ruppel, Stephen Creekmore, and Edward A. SausvilleIndex

Editorial Reviews

"...represents an outstanding work, which should not be missed in all laboratories dealing with cancer gene therapy." - Neoplasma