Cancer Metastasis: Biologic Basis and Therapeutics by David LydenCancer Metastasis: Biologic Basis and Therapeutics by David Lyden

Cancer Metastasis: Biologic Basis and Therapeutics

EditorDavid Lyden, Danny R. Welch, Bethan Psaila

Hardcover | April 25, 2011

Pricing and Purchase Info

$302.92

Earn 1515 plum® points
Quantity:

In stock online

Ships free on orders over $25

Not available in stores

about

Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.
Title:Cancer Metastasis: Biologic Basis and TherapeuticsFormat:HardcoverDimensions:660 pages, 10.98 × 8.46 × 1.22 inPublished:April 25, 2011Publisher:Cambridge University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0521887216

ISBN - 13:9780521887212

Reviews

Table of Contents

Overview Josh Fidler; 1. Introduction to basic research Harold Moses; Part I. Basic Research: 2. Animal models of metastasis Janet Price; 3. Non-traditional models of metastasis including drosophilia Elisa Woodhouse; 4. Computational models of metastasis Wayne Kendal; 5. Metastatic inefficiency and tumor dormancy Ann Chambers; 6. The role of the epithelial-mesenchymal transition (EMT) and MET in metastasis Erik Thompson, Donald Newgreen, and Lilian Soon; 7. Proteolytic pathways in metastasis Johanna Joyce; 8. The role of matrix metalloproteinases in tumor invasion and metastasis Barbara Fingleton; 9. The role of the urokinase system in invasion and metastasis Julio Aguirre-Ghiso; 10. Apoptotic and anoikis mechanisms controlling steps of the metastatic cascade Kounosuke Watabe; 11. Intra-vital video microscopy to visualize invasion and metastasis Erik Sahai; 12. The influence of inflammation and chemokines in metastasis Michael Karin; 13. How aging and cellular senescence influences metastasis Futoshi Okada and Hiroshi Kobayashi; 14. Hematopological vs. lymphatic metastasis: a comparison of tumor cell interactions with vascular vs. lymphatic endothelium Marc Achen, Steven Stacker, and Tara Karezis; 15. The role of microparticles in metastasis Hector Peinado and Bethan Psaila; 16. Endothelial-specific markers that determine organ-specificity of metastasis Renata Pasqualini; 17. Mechanisms of organ selectivity Yibin Kang; 18. Growth regulatory pathways that determine organ selectivity of metastasis Suzanne Eccles; 19. The pre-metastatic niche Mariannna Papaspyridonos and Rosandra Kaplan; 20. Metastasis-promoting genes Paul Fisher; 21. Metastasis-suppressor genes Patricia Steeg and Carrie Rinker-Schaeffer; 22. Epigenetic regulation of metastasis Manel Esteller; 23. Host determinants of metastatic potential Nigel Crawford; Part II. Clinical Research: 24. Introduction to clinical section Nancy E. Davidson; 25. Sarcomas Lee Helman and Chand Khanna; 26. Neuroblastoma Nai Kong Cheung; 27. Retinoblastoma David Abramson; 28. Primary brain tumors and cerebral metastases Mitchel Berger; 29. Head and neck Ketayun Dinshaw; 30. Melanomas John Kirkwood; 31. Gastric Yasuhide Yamada; 32. Pancreas José Eduardo Monteiro Cunha; 33. Liver (primary and hepatic metastases) Zhao-you Tang; 34. Colon Andrea Wang-Gillam; 35. Lung Rafael Rosell-Costa; 36. Thyroid Michael Tuttle; 37. Kidney cancer metastasis Jean Jacques; 38. Bladder Dan Theodorescu; 39. Myeloma/ Lymphoma G. David Roodman; 40. Breast metastasis Heather L. McArthur, Clifford A. Hudis, and Patrick Morris; 41. OBGYN S. Diane Yamada; 42. Prostate cancer metastasis Kenneth Pienta; 43. Testicular and germ cell Robert Hromas; 44. Proteomics and molecular markers Lance Liotta; 45. Bone marrow / MRD Klaus Pantel; 46. Sentinel lymph nodes Jeffrey Gershenwald; 47. Molecular imaging and metastasis Lily Wu; 48. Complications of bone metastases including nerve pain Robert E. Coleman; 49. Coagulation Simon Karpatkin and David Green; 50. Nanoparticles P. Charles Lin; 51. Metronomics Robert Kerbel; 52. Therapeutics Paul Elvin; 53. Immunotherapy Pier-Luigi Lollini, Patrizia Nanni and Carla DeGiovanni; 54. Radiotherapy Hak Choy; 55. Regulatory issues surrounding clinical trials of anti-metastatic therapies George W. Sledge, Jr.

Editorial Reviews

"Metastasis is the next frontier for cancer researchers and clinicians, and this book can help chart the way to conquer it."
Victoria Aranda, Associate Editor, Nature Medicine