Cardiac Mechano-Electric Coupling and Arrhythmias

Hardcover | September 28, 2011

EditorPeter Kohl, Frederick Sachs, Michael R. Franz

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Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically inducedarrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, right through to patient-based observations and insight emerging from clinical trials. The information providedcarefully highlights both consensus insight and current shortcomings in our understanding of cardiac mechano-electric coupling. The book has been thoroughly revised and expanded since publication of the first edition in 2005, extensively updated to reflect recent developments in the field, and now offers a more balanced view of mechano-electrical interactions in the heart and develops a more clinical focus. Written with thepractising cardiologist and junior doctor in mind, it offers interesting new insight for the established physician with an interest in cardiac arrhythmogenesis and heart rhythm management.

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Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically inducedarrhythmias and mechanical interventions for heart rhy...

Professor Peter Kohl, Chair in Cardiac Biophysics and Systems Biology at the National Heart and Lung Institute, Imperial College London, UK; Reader in Cardiac Physiology at the University of Oxford; Senior Fellow of the British Heart Foundation. His research crosses traditional boundaries between fields (engineering, biophysics, biolo...

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Format:HardcoverDimensions:512 pages, 10.87 × 8.62 × 0.98 inPublished:September 28, 2011Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199570167

ISBN - 13:9780199570164

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Table of Contents

Basic Science, Section I: Sub-Cellular Mechanisms of Cardiac Mechano-Electric Coupling1. Boris Martinac and Anna Kloda: Evolutionary origins of stretch-activated ion channels2. Frederick Sachs: SACs in the heart3. Eric Honore and Amanda Patel: The mechano-gated K2P channel TREK-1 in the cardiovascular system4. Clive M. Baumgarten, Wu Deng, and Frank J. Raucci, Jr.: Cell Volume-Sensitive Ion Channels and Transporters in Cardiac Myocytes5. Gentaro Iribe and Peter Kohl: Non-sarcolemmal stretch-activated channels6. Catherine E. Morris: Pacemaker, potassium, calcium, sodium: stretch modulation of the voltage-gated channels7. Sarah Calaghan: Role of caveolae in stretch-sensing: implications for mechanoelectric coupling8. Thomas M. Suchyna and Frederick Sachs: The membrane/cytoskeleton interface and stretch-activated channels9. Michiel Helmes and Henk Granzier: Cardiomyocyte stretch sensing10. John Jeremy Rice and Donald M. Bers: The response of cardiac muscle to stretch: Calcium and force11. Jean-Luc Balligand and Chantal Dessy: Stretch effects on second messengers12. Kevin Kit Parker: Functional implications of Myocyte ArchitectureBasic Science, Section II: Cellular Manifestations of Cardiac Mechano-Electric Coupling13. Patricia J. Cooper and Ursula Ravens: Mechanical modulation of pacemaker electrophysiology14. Michael R. Franz: Mechano-electric coupling in working cardiomyocytes: diastolic and systolic effects15. Chang Ahn Seol, Won Tae Kim, Jae Boum Youm, Yung E. Earm, and Chae Hun Leem: Mechano-sensitivity of pulmonary vein cells: implications for atrial arrhythmogenesis16. Henk E.D.J. ter Keurs, Ni Diao, Nathan P. Deis, Mei L Zhang, Yoshinao Sugai,. Guy Price, Yuji Wakayama, Yutaka Kagaya, Yoshinao Shinozaki, Penelope A Boyden, Masahito Miura, Bruno DM Stuyvers: Heterogeneity of sarcomere length and function as a cause of arrhythmogenic calcium waves17. Kenneth R. Laurita: Cellular mechanisms of arrhythmogenic cardiac alternans18. Andre G. Kleber and Jeffrey E. Saffitz: Remodeling of gap junctions in ventricular myocardium: Effects of cell-to-cell adhesion, mediators of hypertrophy and mechanical forces19. Troy A. Baudino and Thomas K. Borg: The origin of fibroblasts, ECM and potential contributions to cardiac mechano-electric coupling20. Leslie Tung and Susan A. Thompson: Advantages and pitfalls of cell cultures as model systems to study cardiac mechanoelectric couplingBasic Science, Section III: Multi-cellular manifestations of mechano-electric coupling21. Vladimir S. Markhasin, Alexander Balakin, Yuri Protsenko, and Olga Solovyova: Activation sequence of cardiac muscle in simplified experimental models: Relevance for cardiac mechano electric coupling22. Peter Kohl: 23. Michael R. Franz and Frank Bode: Acute stretch effects on atrial electro-physiology24. Christian Bollensdorff and Max J Lab: Stretch effects on potassium accumulation and alternans in pathological myocardium25. Robert W. Mills, Adam T. Wright, Sanjiv M. Narayan, and Andrew D. McCulloch: The effects of wall stretch on ventricular conduction and refractoriness in the whole heart26. Darwin Jeyaraj and David S. Rosenbaum: Mechanical triggers of long-term ventricular electrical remodeling27. Granfeldt, Jiang, Shi, and Vinten-Johansen: Mechanisms of mechanical pre- and postconditioningTranslational Science, Section IV: Integrated model systems to study specific cases of cardiac MEC and arrhythmias28. Ulrich Schotten: Mechano-electric coupling in chronic atrial fibrillation29. Omer Berenfeld: Mechanically induced pulmonary vein ectopy - insight from animal models30. Ed White, David Benoist, and Olivier Bernus: Regional variation in mechano-electric coupling: The right ventricle31. Frank Bode and Michael R. Franz: Mechanical induction of arrhythmia in the ex-situ heart: insight into Commotio Cordis32. Larissa Fabritz and Paulus Kirchhof: Arrhythmias in murine models of the mechanically impaired heart33. Flavia Ravelli and Michela Mase: Studying cardiac mechano-sensitivity in man34. Vicky Y. Wang, Martyn P. Nash, Ian J. LeGrice, Alistair A. Young, Bruce H. Smaill and Peter J. Hunter: Mathematical models of cardiac structure and function: mechanistic insights from models of heart failure35. Elizabeth M. Cherry: Mathematical models of human atrial mechano-electrical coupling and arrhythmias36. Natalia A. Trayanova, Viatcheslav Gurev, Jason Constantino, Yuxuan Hu: Mathematical models of ventricular mechano-electric coupling and arrhythmiaClinical Relevance, Section V: Pathophysiology of cardiac mechano-electric coupling: general aspects37. Peter Taggart and Peter Sutton: Load dependence of ventricular repolarisation38. Rainer Schimpf and Martin Borggrefe: Is the U wave in the electrocardiogram a mechanoelectrical phenomenon?39. John V. Tyberg: Mechanical modulation of cardiac function: Role of the pericardium40. Geoffrey Lee; Prashanthan Sanders; Joseph B. Morton and Jonathan M. Kalman: Mechanically-induced electrical remodelling in human atrium41. JM van Opstal, Y Blaauw, and HJGM Crijns: Drug effects and atrial fibrillation: potential and limitations42. Eugene A. Sosunov, Evgeny P. Anyukhovsky, and Michael R. Rosen: Stretch as a mechanism linking short- and long-term electrical remodeling in the ventricles43. Michiel J Janse and Ruben Coronel: Volume and pressure overload and ventricular arrhythmogenesis44. Masatoshi Yamazaki and Jerome Kalifa: Stretch effects on fibrillation dynamicsClinical Relevance, Section VI: Pathophysiology of cardiac mechano-electric coupling: specific cases45. Mark S. Link: Commotio cordis: Sudden death from blows to the chest wall46. Takeshi Aiba and Gordon F. Tomaselli: Repolarization changes in the synchronously and dys-synchronously contracting failing heart47. Steven N. Singh and Pamela Karasik: Ventricular arrhythmias in heart failure: Link to hemodynamic load48. Annerie M.E. Moers and Paul G.A. Volders: Mechanical heterogeneity and aftercontractions as trigger of torsades des pointes49. Ruben Coronel, Natalia Trayanova, Xiao Jie, and Michiel J. Janse: Stretch-induced arrhythmias in ischaemiaClinical relevance, Section VII: Mechano-electric coupling as a mechanism involved in therapeutic interventions50. Tommaso Pellis and Peter Kohl: Antiarrhythmic effects of acute mechanical stimulation51. Peter Taggart and Peter Sutton: Termination of arrhythmias by haemodynamic unloading52. Derek J. Dosdall, Harish Doppalapudi, and Raymond E. Ideker: Mechanical modulation of defibrillation and resuscitation efficacy53. Paul J. Joudrey, Roger J. Hajjar and Fadi G. Akar: Anti- and pro-arrhythmic effects of cardiac assist device implantation54. Nico H. L. Kuijpers and Frits W. Prinzen: Anti- and pro-arrhythmic effects of cardiac resynchronization therapyClinical relevance, Section VIII: Evidence for mechano-electric coupling from clinical trials55. Matthias Hammwohner and Andreas Goette: Evidence for mechano-electric coupling from clinical trials on AF56. Paulus Kirchhof and Gunter Breithardt: Evidence for mechano-electric coupling from clinical trials in heart failure57. Hayden Huang, Angeliki Asimaki, Frank Marcus, and Jeffrey E. Saffitz: Mechano-electrical coupling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy58. Nico R.L. Van de Veire and Jeroen J. Bax: Evidence for mechano-electric coupling from clinical trials on cardiac resynchronization therapy59. Cesare M. Terracciano, Michael Ibrahim, Manoraj Navaratnarajah and Magdi H. Yacoub: Mechano-electric coupling in patients treated with ventricular assist devices: insights from individual cases and clinical trialsOutlook, Section IX: Novel directions in cardiac mechano-electic coupling60. Fanjie Meng and Frederick Sachs: Measuring strain of structural proteins in vivo in real time61. David G. Allen and Marie L. Ward: Roles of SAC beyond M-E Transaction62. Elliot J. Howard and Jeffrey H. Omens: Distributions of myocyte stress, strain and work in normal and infarcted ventricles63. Elisa E. Konofagou and Jean Provost: Evolving concepts in measuring ventricular strain in the canine and human hearts: non-invasive imaging64. Douglas A. Hettrick: Evolving concepts in measuring ventricular strain in the human heart: impedance measurements65. Ed White: Mechanosensitive channel blockers: A new class of antiarrhythmic drugs?