Cell Adhesion

Paperback | February 1, 2002

EditorMary C Beckerle

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Cell adhesion plays a central role in development and disease. Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book is divided into two parts. The first section provides a discussion of the structure andfunction of the seven major classes of cell adhesion molecules: integrins, cadherins, selectins, heparan sulfate proteoglycans, the immunoglobulin superfamily, the ADAMs proteins, and transmembrane protein tyrosine phosphatases. The roles of these cell adhesion proteins in important processes suchas cell mediated immunity, development and disease are discussed. In the second section, the molecular organization and function of junctional complexes, regions of the cell surface that are highly specialized for cell adhesion, are examined. Junctional complexes are now known to mediate adhesiveinteractions and contribute to transmembrane signaling events that dramatically influence cell behaviour.The biochemical organization of the adhesive membranes and the molecular mechanisms by which they transmit information to the cell are addressed.Written by contributors among the most prominent in the field, Cell Adhesion covers a wide range of topics in a single volume. It will be a great resource for students, teachers and researchers.

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Cell adhesion plays a central role in development and disease. Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book is divided into two parts. The first section provides a discussion of the structure andfunction of the seven major classes of cell ...

Mary Beckerle is at Huntsman Cancer Institute and Department of Biology, University of Utah, USA.

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Format:PaperbackDimensions:426 pages, 9.69 × 7.44 × 0.95 inPublished:February 1, 2002Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199638713

ISBN - 13:9780199638710

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Table of Contents

1. Hansjurgen Volkmer: The immunoglobulin superfamily of cell adhesion molecules2. Rodger P McEver: Selectins3. Glenn L Radice and Masatoshi Takeichi: Cadherins4. Bette Dzamba, Margaret Bolton and Douglas Desimone: The integrin family of cell adhesion molecules5. Ofer Reizes, Pyong Woo Park, and Merton Bernfield: Cell surface heparan sulfate proteoglycans6. Judith White, Dora Bigler, Michellee Chen, Yuji Takahashi, and Tyra Wofsberg: ADAMs7. Susann Brady-Kalnay: Protein tyrosine phosphatases8. Cara Gottardi, Carien Niessen, Barry Gumbiner: The adherens junction9. Lynda Peterson and Keith Burridge: Focal adhesions and focal complexes10. Leslie Bannon, Lawrence Goldfinger, Jonathan Jones, Kathleen Green: Desmosomes and hemidesmosomes11. Shoichiro Tsukita, Mikio Furuse, Masahiko Itoh: The tight junction