Cell Culture Methods for in vitro Toxicology by G. StaceyCell Culture Methods for in vitro Toxicology by G. Stacey

Cell Culture Methods for in vitro Toxicology

byG. StaceyEditorAlan Doyle, Margherita Ferro

Paperback | December 4, 2010

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Cell Culture Methods for in vitro Toxicologyintroduces the reader to a range of techniques involved in the use ofin vitrocell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating toin vitrocell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation these are key issues forin vitrosystems addressing the `3Rs' principle. Up-to-date overviews deal with the use of cells from liver, brain and intestine. In addition, biochemical analysis of cell responses, biotransformation pathways in cells and recombinant approaches to the early detection of cell stress are also covered in detail.
Prominent features ofin vitrotechnologies also include regulation, biosafety and standardisation. Dedicated chapters deal with these issues in a practical way in order to lead the reader to the right source of information. This book provides an up-to-date, informative and practical review of cell culture methods forin vitrotoxicology. It will be of equal benefit to students and experienced toxicologists with little experience ofin vitrocell culture.
Title:Cell Culture Methods for in vitro ToxicologyFormat:PaperbackDimensions:153 pages, 23.5 × 15.5 × 0.02 inPublished:December 4, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9048159369

ISBN - 13:9789048159369

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Table of Contents

List of Contributors. Preface by the Editor. 1. Standardisation for in vitro Toxicity Test; M. Ferro, A. Doyle. 2. Application of Cell Cultures to Toxicology; I. Freshney. 3. Immortalisation of Primary Cells; G. Stacey, C. MacDonald. 4. Safety Considerations for in vitro Toxicology Testing; B. Jones, G. Stacey. 5. The Drug Metabolizing Enzymatic System and the Experimental Tools Used for in vitro Toxicology for Metabolic Studies; E. Testai. 6. Cell Culture Models for Hepatotoxicology; T. Battle, G. Stacey. 7. Intestinal Cell Culture Models: Applications of Toxicology and Pharmacology; Y. Sambruy, S. Ferruzza, G. Ranaldi, I. de Angelis. 8. Cell Culture Models for Neurotoxicology; G. Stacey, B. Viviani. 9. Recombinant Cell Lines for Stress Reporter Assays; M. Fischbach, P. Bromley. Index.