Cell Cycle Inhibitors in Cancer Therapy: Current Strategies by Antonio GiordanoCell Cycle Inhibitors in Cancer Therapy: Current Strategies by Antonio Giordano

Cell Cycle Inhibitors in Cancer Therapy: Current Strategies

EditorAntonio Giordano, Kenneth J. Soprano

Paperback | November 19, 2010

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Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.
Title:Cell Cycle Inhibitors in Cancer Therapy: Current StrategiesFormat:PaperbackDimensions:336 pagesPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617372579

ISBN - 13:9781617372575

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Table of Contents

Cdk Inhibitors: Background and IntroductionGiulia De Falco, Catherine Soprano, and Antonio Giordanop27, A Prognostic Indicator Reflecting...?Andrew KoffCell Cycle Control of Transcription at the G1/S Phase TransitionAndré J. van Wijnen, Gary S. Stein, Janet L. Stein, and Jane B. LianTumor-Suppressor Genes as Diagnostic ToolsLorenzo Leoncini, Cristiana Bellan, Caterina Cinti, and Antonio GiordanoRegulation of Cell Cycle and ApoptosisLucio MieleCDK Inhibitors as Targets of Chemoprevention AgentsJoanna K. Sax and Wafik S. El-DeiryCell Cycle Regulatory Genes as Targets of RetinoidsKenneth J. Soprano, Sijie Zhang, Dongmei Zhang, William F. Holmes, Valeria Masciullo, Antonio Giordano, and Dianne R. SopranoModulators of Cyclin-Dependent Kinases: A Novel Therapeutic Approach for the Treatment of Neoplastic DiseasesAdrian M. SenderowiczCell Cycle Regulators: Interactions and Their Role in Diagnosis, Prognosis, and Treatment of CancerPaul J. van Diest and Rob J. A. M. MichalidesCell Cycle Regulators as Targets of Anticancer TherapyMikhail V. BlagosklonnyMammalian CDK Inhibitors as Targets of Ubiquitinization in CancerValeria Masciullo, Kenneth J. Soprano, and Antonio GiordanoSynthetic Oligopeptides as Cancer Cell Cycle ModulatorsAnna Severino, Armando Felsani, Antonio Giordano, and Marco G. PaggiIndex

Editorial Reviews

"Cell Cycle Inhibitors in Cancer Therapy is an excellent book that summarizes the most up-to-date information on cell cycle control mechanisms, the naturally occurring and synthetic molecules that modulate cell cycle events, and their potential roles in cancer therapeutics and prevention." -Pharmaceutical Research