Cell Death and Diseases of the Nervous System by Vassilis E. KoliatsosCell Death and Diseases of the Nervous System by Vassilis E. Koliatsos

Cell Death and Diseases of the Nervous System

byVassilis E. KoliatsosEditorRajiv R. Ratan

Paperback | October 21, 2012

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It is an honor to be asked to write a foreword for this timely book, which assembles contributions from authorities working in the area of pathological nervous system cell death, and has been expertly edited by Vassilis Koliatsos and Rajiv Ratan. That the inap­ propriate demise of brain or spinal cord cells is at the root of many neurological diseases has been appreciated since the early days of microscopic neuropathology, but it has only been in the last decade or so that pervasive therapeutic nihilism has lifted. In the journey of medical progress, we have reached the shores of a marvelous new land. Three major scientific thrusts in particular have converged to produce the press of ideas covered here. First, burgeoning information about the fundamental nature of central nervous system cell--(;ell signaling, both the fast signaling mediated by conventional neu­ rotransmitters and the usually slower signaling mediated by neuromodulators and growth factors. A central theme emerging in recent years has been the duality of these signaling mechanisms, which serve the nervous system in health, but which can become the very mediators of neuronal or glial cell degeneration in disease settings. Glutamate-mediated neurotransmission and excitotoxicity have been the defining and best-studied examples, but many other examples have also emerged. Second, delineation of the molecular under­ pinnings of programmed cell death, and an appreciation of their awesome power.
Title:Cell Death and Diseases of the Nervous SystemFormat:PaperbackDimensions:683 pagesPublished:October 21, 2012Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1461272130

ISBN - 13:9781461272137

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Table of Contents

Part I.Definitions-Cellular and Molecular Mechansims. Apoptosis Versus Necrosis: How Valid a Dichotomy for Neurons?,Peter G. H. Clarke. Asynchronous Death as a Characteristic Feature of Apoptosis,Randall N. Pittman, Conrad A. Messam, and Jason Mills. Free Radicals and Mitochondria Dysfunction in Excitotoxicity and Neurodegenerative Diseases, James A. Dykens. Calcium and Cell Death, Marcel Leist and Pierluigi Nicotera. Proteases: Critical Mediators and Apoptosis, Anthony Rosen and Livia Casciola-Rosen. The Cell Cycle and Neuronal Cell Death, Robert S. Freeman. Part II.Animal Models. Neuronal Cell Death in C. elegans, Dewey Royal and Monica Driscoll. Cellular Interactions that Regulate Programmed Cell Death in the Developing Vertebrate Nervous System, Michael J. Burek and Ronald J. Oppenheim. Axotomy-Induced Motor Neuron Death, Jeffrey L. Elliott and William D. Snider. Excitotoxic Cell Death, John W. Olney and Masahiko J. Ishimaru. Neurotoxins and Neuronal Death: An Animal Model of Excitoxicity, Elizabeth O'Hearn and Mark E. Molliver. Part III.Nerve Cell Death in Human Diseases. DNA Repair in the Nervous System, Brian G. Fuller and Vilhelm Bohr. Cell Death and the Mitochondrial Encephalomyopathies, Kevin M. Flanigan and Rajiv Ratan. Viral Encephalitis, J. Marie Hardwick, David N. Irani, and Diane E. Griffin. Mechanisms of Cell Injury in Prion Diseases, David R. Borchelt. Blood Flow, Energy Failure, and Vulnerability to Stroke, James J. Vornov. Epilepsy and Cell Death, Cheolsu Shin and Ki-Hyeong Lee. Trauma to the Nervous System, W. Dalton Dietrich. Approaches to the Study of Oligodendroglial Death, Stephen A. Back, Paul A. Rosenberg, and Joseph J. Volpe. Motor Neuron Disease, Bruce A. Rabin and David R. Borchelt. Cerebellar Degenerations, Katherine Wood. Parkinson's Disease, Robert E. Burke. Huntington's Disease and DRPLA: Two Glutamine Repeat Diseases, Christopher A. Ross, Mark W. Becher, and Vassilis E. Koliatsos. Cortical Destruction and Cell Deathin Alzheimer's Disease, Heiko Braak and Eva Braak. HIV-1 Infection of the CNS: Evidence for Apoptosis of Neural Cells, Harris A. Gelbard. Neurotoxicity of Drugs of Abuse, Jean Lud Cadet. Schizophrenia, Steven E. Arnold. Part IV. Approaches in Treating Nerve Cell Death.Trophic Factors as Therapeutic Agents for Diseases Characterized by Neuronal Death,Vassilis E. Koliatsos and Italo Mocchetti. Brain Derived Neurotrophic Factor as a Therapeutic Agent for ALS, Dana C. Hilt, James A. Miller, and Errol Malta. Calcium Chelators, Michael Tymianski. Antiglutamate Therapies for Neurodegenerative Disease: Amyotrophic Lateral Sclerosis, Osnat Bar-Peled and Jeffrey D. Rothstein. Antioxidants and the Treatment of Neurological Disease, Rajiv R. Ratan.