Cell Growth, Differentiation and Senescence: A Practical Approach

Paperback | November 25, 1999

EditorGeorge Studzinski

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There are three main themes running through this volume. First, basic methods for measurement of cell proliferation are introduced and explained with reference to various systems, primarily in vitro, but in vivo procedures are also illustrated. The second theme is growth signalling, and isexemplified by methods for the analysis of transduction pathways for growth, beginning at the cell membrane and leading to the cell nucleus. The last theme presented here is growth cessation, illustrated by several systems for induction of cell differentiation, and of cell senescence. The emphasisthroughout the book is on human cell systems, making it particularly relevant to scientists interested in human disease, especially cancer. Importantly, well proved methods for studying cell growth are supplemented by some novel approaches, e.g., studies of cell cycle checkpoints, cell spheroids,and nuclear architecture. Only two chapters have been retained, in an updated form from Cell Growth and Apoptosis, the predecessor volume. The book is written by a team of scientists highly experienced in procedures they describe, and offer details and hints found valuable in their ownlaboratories; thus, variants of the same general methods can be found in different chapters. These should be helpful to beginning as well as experienced investigators, and are designed to stimulate new approaches to old and new questions.

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From the Publisher

There are three main themes running through this volume. First, basic methods for measurement of cell proliferation are introduced and explained with reference to various systems, primarily in vitro, but in vivo procedures are also illustrated. The second theme is growth signalling, and isexemplified by methods for the analysis of tr...

George Studzinski is at New Jersey Medical School.
Format:PaperbackPublished:November 25, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199637687

ISBN - 13:9780199637683

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Table of Contents

Preface; Chapter 1 Wieder: Selection of Methods for Measuring Proliferation; Chapter 2 Skehan: Cell Growth and Cytotoxicity Assays; Chapter 3 Durand: Cell Growth and Kinetics in Multicell Spheroids; Chapter 4 O'Connor and Jackman: Assessment of Checkpoint Controls of Cell Growth; Chapter 5Bishayee: Assessment of the Role of Growth Factors and their Receptors in Cell Proliferation; Chapter 6 Alessandrini: Analysis of Growth-Signaling Protein Kinase Cascades; Chapter 7 Juan et al: Cytometric Analysis of the pRB Pathway; Chapter 8 Cosenza et al: Methods for Oncogene Detection; Chapter 9Stein et al: Isolation and Visualization of the Principal Components of Nuclear Architecture; Chapter 10 Wolf and Flanagan: Antisense Oligonucleotides - tools for elucidating gene function; Chapter 11 Moore and Studzinski: Human Leukemia Cells as a Model Differentiation System; Chapter 12 Cross andKalley: Induction of Differentiation of Human Intestinal Cell in Vitro;Chapter 13 Thalhammer and Cross: Proliferation.... [data incomplete]

Editorial Reviews

" ... is very useful for cell biologists, both newcomers and more experienced ones" Cell Biology International