Cell Polarity In Development And Disease

Paperback | October 1, 2017

byDouglas W Houston

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Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. Although many of the molecular/genetic signalling pathways underlying many disorders are well studied biochemically, how the relevant cellular organization integrates with various signalling molecules is often less clear. This book addresses these ideas, providing a basic resource for understanding the biology of polarity and offering a starting point for those thinking of targeting cell polarity for translational medical research. Provides basic science understanding of cell polarity disease and development Covers diseases affecting polarized epithelial tissues in the lung and kidney, and in the progression of cancer Includes historical context of cell polarity research for potential future breakthroughs

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Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the ons...

Douglas Houston is an Associate Professor at the University of Iowa. His research is focused on a central problem in developmental biology: how a single-celled egg differentiates into an organism containing many different cell and tissue types. Using frog embryos as a model organism, he and his lab have isolated numerous novel genes wi...

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Format:PaperbackDimensions:336 pages, 8.75 × 6.35 × 0.68 inPublished:October 1, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128024380

ISBN - 13:9780128024386

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Table of Contents

1. Overview of cell polarity: insights from model organisms and cellular systems
2. Cell polarity in the egg and early embyro- mammal
3. Pluripotency and cell polarity
4. The role of cell polarity in adult stem cell maintenance
5. Integration of cell polarity and growth factor signaling
6. Cell polarity and the onset and progression of cancer
7. Cell division and cell polarity
8. Polarized membrane/vesicle trafficking and disease
9. Polarized microtubule transport and disease
10. Regulation of cell polarity in cell/neuronal migration
11. Apical and planar cell polarity in ciliated epithelia
12. Renal epithelial cell polarity and disease
13. Hepatic cell polarity and disease
14. Epidermal cell polarity and disease
15. Cell polarity and sensory cell defects