Cell Proliferation in Cancer: Regulatory Mechanisms of Neoplastic Cell Growth

Hardcover | April 30, 1999

EditorL. Pusztai, C. E. Lewis, E. Yap

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Research in cellular and molecular biology has reached the point now where it is possible to begin to see how the different fields of cancer genetics/oncogene research and intercellular communication form an integrated molecular model for the regulation of normal and neoplastic cellproliferation. A number of important discoveries in this field during the past few year shave greatly increased our understanding of cancer biology and have offered new diagnostic and prognostic parameters in oncology. This information also holds the promise of novel, more effective therapeuticapproaches to cancer. However, it is becoming increasingly difficult for an individual to maintain a wide and informed knowledge of current concepts in this rapidly moving field, or to form an integrated overview of the myriad factors involved in neoplastic cell proliferation.This book comprises a number of state-of-the-art reviews written by leading scientists. Each chapter gives a concise overview of specific intra-and intercellular events which regulate the proliferation of neoplastic cells, and the established and potential clinical implications of thesedevelopments. The topics have been selected to cover major recent advances in our understanding of the molecular events which govern cell division. It is expected that students, scientists and clinicians working in the fields of oncology, pathology, and molecular/cellular biology would find thisvolume invaluable as a stimulating source of information.

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From the Publisher

Research in cellular and molecular biology has reached the point now where it is possible to begin to see how the different fields of cancer genetics/oncogene research and intercellular communication form an integrated molecular model for the regulation of normal and neoplastic cellproliferation. A number of important discoveries in t...

From the Jacket

This book comprises a number of state-or-the-art reviews written by leading scientists. Each chapter gives a concise overview of specific intra- and intercellular events which regulate the proliferation of neoplastic cells, and the established or potential clinical implications of these developments. The topics have been selected to co...

Lajos Pusztai is at St Mary's Hospital, Rochester, NY. Claire Lewis is at University of Oxford.

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Format:HardcoverDimensions:418 pages, 9.21 × 6.14 × 1.06 inPublished:April 30, 1999Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198547919

ISBN - 13:9780198547914

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Table of Contents

Introduction: Cell proliferation and carcinogenesis1. The cell cycle2. Oncogenes and tumour-suppressor genes3. Oncogenes and tumour-suppressor genes as prognostic indicators in the development of human tumours4. The role of cytokines in tumour progression5. Abnormal growth factor networks in neoplasia6. The fibroblast growth factor family: Multifunctional regulators of cell proliferation7. The potential and limitations of cytokine/growth factor manipulation in cancer therapy8. Neuropeptides9. Hormonal regulation of cancer cell growth10. Retinoids in neoplasia11. Metastasis: Secondary proliferation in distant organs12. Apoptosis: a role in neoplasia?13. Cell proliferation and its role in carcinogenesis and therapy

Editorial Reviews

`the book is a pleasure to read with critical evaluation of information from many sources followed by a careful selection of appropriate references ... When appropriate, the authors move from genetic study and give digestible and interesting information about environment an biochemical factorsthat might contribute to the prevention, diagnosis and therapy of this disease. The book is suitable for researchers at all levels of training and will stimulate new directions and fresh ideas that help the understanding of the molecular and genetic basis of cancer.'Eugene Lukanidin, FEBS Letters 403 (1997)