Cell Signalling

Paperback | February 20, 2010

byJohn Hancock

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Signalling within and between cells is an essential part of many biological processes, from the development of the body, to the activity of our immune system. Recent advances in molecular cell biology have allowed us to identify the components of signalling pathways, and examine how theyinteract to form the carefully orchestrated and controlled networks upon which the complexity of a living organism is built.Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create signalling pathways, whichare so crucial to the survival of many living organisms.Cell Signalling presents a carefully structured introduction to this intricate subject, introducing those conserved features that underlie many different extra- and intracellular signalling systems. * A focus on generic components of extra- and intracellular signalling pathways allows the student to gain a thorough understanding of the underlying principles of cell signalling before exploring how the individual components inteeract to form complex signalling pathways* The ubiquity of key signalling mechanisms is highlighted, enabling students to see how similar mechanisms are conserved and harnessed in many different biological systems* The student is directed to carefully chosen further reading articles, allowing them to readily explore key topics in more detailThe Online Resource Centre to accompany Cell Signalling features:For students:* Links to useful websites* Hyperlinked referencesFor Lecturers:* All figures from the book

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From the Publisher

Signalling within and between cells is an essential part of many biological processes, from the development of the body, to the activity of our immune system. Recent advances in molecular cell biology have allowed us to identify the components of signalling pathways, and examine how theyinteract to form the carefully orchestrated and c...

Dr John Hancock is Reader in Molecular Biology in the Faculty of Applied Science at the University of the West of England, Bristol, UK.

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Format:PaperbackDimensions:352 pagesPublished:February 20, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199232105

ISBN - 13:9780199232109

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Table of Contents

Figure LegendsPrefaceAbbreviationsPart I: An overview of cell signalling1. Aspects of cellular signalling2. Pathways are the key to signalling3. A look at some of the history and techniques of cell signallingPart II: Components which comprise signalling pathways4. Extracellular signals: hormones, cytokines and growth factors5. Detection of extracellular signals: the role of receptors6. Protein Phosphorylation, kinases and phosphatases7. Cyclic nucleotides, cyclases and G proteins8. Inositol phosphate metabolism and roles of membrane lipids9. Intracellular calcium: Its control and role as an intracellular signal10. Reactive oxygen species, reactive nitrogen species and redox signallingPart III: Selected examples of signalling pathways and events11. Insulin and the signal transduction cascades it invokes12. Perception of the environment13. Signalling in development and for the regulation of gene expression14. Life, death and apoptosisPart IV: Final thoughts15. Cell Signalling: importance, complexity, and futureIndex

Editorial Reviews

"This is a valiant attempt to bring together a huge and rapidly growing amount of material. The presentation is logically organized and covers the essentials of the topic at a level suitable for undergraduates." --Dr Gerry Shaw, McKnight Brain Institute, University of Florida