Cellular and Molecular Neurophysiology

Other | February 1, 2008

byHammond, Constance, Constance Hammond

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This third edition is the new, thoroughly revised edition of the only current, established and authoritative text focusing on the cellular and molecular physiology of nerve cells. Previously titledCellular and Molecular Neurobiology, the new title better reflects this focus. The book is hypothesis driven rather than just presenting the facts, and the content is firmly based on numerous experiments performed by the top experts in the field. While the book does cover the important facts, it also presents the background for how researchers arrived at this knowledge to provide a context for the field. It teaches not only how excitable cells work in detail, but also how to construct and conduct intelligent research experiments. This book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike.

* 80% new or updated material
* Fifteen appendices describing neurobiological techniques are interspersed in the text
* Now in full color throughout, with more than 400 carefully selected and constructed illustrations
* Provides an instructor website with all the images in electronic format, plus additional material

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From the Publisher

This third edition is the new, thoroughly revised edition of the only current, established and authoritative text focusing on the cellular and molecular physiology of nerve cells. Previously titledCellular and Molecular Neurobiology, the new title better reflects this focus. The book is hypothesis driven rather than just presenting the...

Constance Hammond is an INSERM director of research at the Mediterranean Institute of Neurobiology. A renowned Parkinson's disease investigator, in 2012 she became a Chevalier of the Légion d'Honneur in recognition for her services to scientific communication. Studying biology at the University of Pierre and Marie Curie and the Ecole N...

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Format:OtherDimensions:416 pages, 1 × 1 × 1 inPublished:February 1, 2008Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080556949

ISBN - 13:9780080556949

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Table of Contents

Part I - Neurons: Excitable and Secretory Cells that Establish Synapses.
Chapter 1: Neurons
Chapter 2: Neuron -Glial Cell Cooperation
Chapter 3: Ionic Gradients, Membrane Potential and Ionic Currents
Appendix 3.1: The active transport of ions by pumps and transporters maintain the unequal distribution of ions
Appendix 3.2: The passive diffusion of ions through an open channel
Appendix 3.3: The Nernst equation
Chapter 4: The Voltage-Gated Channels of Na+ Action Potentials
Appendix 4.1: Current clamp recording
Appendix 4.2: Voltage clamp recording
Chapter 5: The Voltage-Gated Channels of Ca+2Action Potentials: Generalization
Appendix 5.1: Fluorescence measures of intracellular Ca2+ concentration
Appendix 5.2: Tail currents
Chapter 6: The Chemical Synapses
Appendix 6.1: Neurotransmitters, agonists and antagonists
Appendix 6.2: Identification and Localization of Neurotransmitters and their Receptors
Chapter 7: Neurotransmitter Release
Appendix 7.1: Quantal nature of neurotransmitter release
Appendix 7.2: The probabilistic nature of neurotransmitter release (the neuromuscular junction as a model)

Part 2 - Ionotropic and Metabotropic Receptors in Synaptic Transmission and Sensory Transduction.
Chapter 8: The Ionotropic Nicotinic Acetycholine Receptors
Appendix 8.1: The neuronal nicotinic receptors
Chapter 9: The Ionotropic GABAA Receptor
Appendix 9.1: Mean time and mean burst duration of the GABAA single-channel current
Appendix 9.2: Non-invasive measurements of membrane potential and of the reversal potential of the GABAA current using cell-attached recordings of single channels
Chapter 10: The Ionotropic Glutamate Receptors
Chapter 11: The Metabotropic GABAB Receptors
Chapter 12: The Metabotropic Glutamate Receptors

Part 3 - Somato-Dendritic Processing and Plasticity of Postsynaptic Potentials.
Chapter 13: Somato-Dendritic Processing of Postsynaptic Potentials
I: Passive Properties of Dendrites
Chapter 14: Subliminal Voltage-Gated Currents of the Somato-Dendritic Membrane
Chapter 15: Somato-Dendritic Processing of Postsynaptic Potentials
II: Role of Subliminal Depolarizing Voltage-Gated Currents
Chapter 16: Somato-Dendritic Processing of Postsynaptic Potentials
III: Role of High Voltage-Activated Depolarizing Currents
Chapter 17: Firing Patterns of Neurons
Chapter 18: Synaptic Plasticity
Appendix 18.1: Depolarization of induced suppression of inhibition (DSI)

Part 4 - The Adult Hippocampal Network.
Chapter 19: The Adult Hippocampal network
Chapter 20: Maturation of the Hippocampal Network