Checkpoint Controls and Cancer: Volume 1: Reviews and Model Systems by Axel H. SchönthalCheckpoint Controls and Cancer: Volume 1: Reviews and Model Systems by Axel H. Schönthal

Checkpoint Controls and Cancer: Volume 1: Reviews and Model Systems

EditorAxel H. Schönthal

Paperback | November 10, 2010

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Prestigious researchers working at the cutting-edges of their fields comprehensively review the complexities of checkpoint controls and the model systems available to study them. The authors introduce all of the important components of checkpoint controls, describe their intricate interactions, and highlight the relevance of these processes to the cancer problem. Additional chapters illustrate the advantages of using such diverse model systems as intact human skin, knockout mice, Xenopus, and yeast, and show how they can cross-fertilize and accelerate research both across disciplines and beyond the boundaries of a particular species. A second volume, Activation and Regulation Protocols, provides readily reproducible experimental protocols to study the molecular components of checkpoint controls and their regulation.
Title:Checkpoint Controls and Cancer: Volume 1: Reviews and Model SystemsFormat:PaperbackDimensions:334 pages, 9.02 × 5.98 × 0.01 inPublished:November 10, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617374261

ISBN - 13:9781617374265

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Table of Contents

Part I. Reviews of Checkpoint Controls, Their Involvement in the Development of Cancer, and Approaches to Their InvestigationG1 and S-Phase Checkpoints, Chromosome Instability, and CancerHiroshi NojimaAnalyzing the G2/M CheckpointGeorge R. Stark and William R. TaylorAnalyzing the Spindle Checkpoint in Yeast and FrogsP. Todd Stukenberg and Daniel J. BurkeCell Cycle Checkpoint Control Mechanisms That Can Be Disrupted in CancerBipin C. Dash and Wafik El-DeiryPart II. Analyzing Checkpoint Controls in Diverse Model SystemsEstablishment of a Cell-Free System to Study the Activation of Chk2Xingzhi Xu and David F. SternAnalyzing Checkpoint Controls in Human SkinSandra Pavey and Brian G. GabrielliGeneration and Analysis of Brca1 Conditional Knockout MiceChu-Xia Deng and Xiaoling XuAnalysis of Cell Cycle Progression and Genomic Integrity in Early Lethal KnockoutsEric J. BrownXenopus Cell-Free Extracts to Study the DNA Damage ResponseVincenzo Costanzo, Kirsten Robertson, and Jean GautierA Xenopus Cell-Free System for Functional Analysis of the Chfr Ubiquitin Ligase Involved in Control of Mitotic EntryDongmin Kang, Jim Wong, and Guowei FangControl of Mitotic Entry After DNA Damage in DrosophilaBurnley Jaklevic, Amanda Purdy, and Tin Tin SuMethods for Analyzing Checkpoint Responses in Caenorhabditis elegansAnton Gartner, Amy J. MacQueen, and Anne M. VilleneuveAssaying the Spindle Checkpoint in the Budding Yeast Saccharomyces cerevisiaeChristopher M. Yellman and Daniel J. BurkePurification and Analysis of Checkpoint Protein Complexes From Saccharomyces cerevisiaeCatherine M. Green and Noel F. LowndesIndex