Chemical Carcinogenesis by Trevor M. PenningChemical Carcinogenesis by Trevor M. Penning

Chemical Carcinogenesis

EditorTrevor M. Penning

Paperback | April 19, 2013

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This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Title:Chemical CarcinogenesisFormat:PaperbackDimensions:456 pagesPublished:April 19, 2013Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617797294

ISBN - 13:9781617797293

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Table of Contents

1.      Historical Overview of Chemical Carcinogenesis2.      Multistage Carcinogenesis3.      Tobacco Smoke Carcinogens and Lung Cancer4.      Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products5.      Heterocyclic Amines: Potential Human Carcinogens6.      Aflatoxins and Hepatocellular Carcinoma 7.      Metabolic Activation of Chemical Carcinogens8.      Detoxication of  Chemical Carcinogens and Chemoprevention9.      Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts, Carcinogenicity, Structure and Function10.  Oxidation and Deamination of DNA by Endogenous Sources11.  Lipid Peroxide-DNA Adducts12.  Chemical Carcinogenesis and  Epigenetics13.  Nucletoide Excision Repair From Bacteria to Humans: Structure-Function Studies14.  Base Excision Repair: Role of DNA Polymerase b in Late Stage Base Excision Repair15.  O6-Alkylguanine-DNA alkyltransferase16.  By-Pass DNA Polymerases17.  Mutagenesis: The Outcome of Faulty Replication of DNA18.  p53 and Ras-Mutation