Chemo Fog: Cancer Chemotherapy-Related Cognitive Impairment by Robert B. RaffaChemo Fog: Cancer Chemotherapy-Related Cognitive Impairment by Robert B. Raffa

Chemo Fog: Cancer Chemotherapy-Related Cognitive Impairment

byRobert B. RaffaEditorRonald J. Tallarida

Hardcover | June 10, 2010

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Cancer patients have benefitted greatly from recent advances in the drugs, dose regimens, and combinations used to treat their primary tumor and for the treatment or prevention of spread of their disease. Due to the advances in chemotherapy and other aspects of prevention, early detection, and treatment modalities, an increasing percentage of patients are surviving the disease. For some types of cancer, the majority of patients live decades beyond their diagnosis. For this they are forever thankful and appreciative of the drugs that helped lead to this increased survival rate. But no drug is devoid of adverse effects. This also applies to chemotherapeutic agents. The acute cytotoxic effects of these agents are well known--indeed are often required for their therapeutic benefit. The chronic adverse effects are varied and in some cases less well known. With the increase in survival rates, there has emerged a new awareness of these chronic adverse effects.
ROBERT B. RAFFA, PhD, is Professor of Pharmacology and Chair of the Department of Pharmaceutical Sciences at Temple University School of Pharmacy in Philadelphia, Pennslyvania. He holds B Chem E and BS degrees in Chemical Engineering and Physiological Psychology, MS degrees in Biomedical Engineering and Toxicology, and a PhD in Pharma...
Title:Chemo Fog: Cancer Chemotherapy-Related Cognitive ImpairmentFormat:HardcoverDimensions:216 pagesPublished:June 10, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441963057

ISBN - 13:9781441963055

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Table of Contents

1. Short Introduction and HistoryRobert B. RaffaAbstractIntroduction and HistoryConclusion2. Patient's PerspectiveRobert B. Raffa and Kathy MartinAbstractIntroductionConclusion3. Oncology Nurse's PerspectiveJamie S. MyersAbstractPrelude: Personal Reflections of an Oncology NurseChemotherapy?Related Cognitive Impairment: The Oncology Nurse PerspectiveOncology Nursing ResearchOncology Nursing EducationConclusion4. Oncology Pharmacist's PerspectiveRachel Clark?VetriAbstractIntroductionConclusion5. The Impact of Chemo Brain on the Patient with a High Grade GliomaMichele R. LucasAbstractBackgroundBrain CancerImpact of Chemo Brain on the PatientImpact of Chemo Brain on the FamilyImpact of Chemo Brain on SocietyConclusion6. Neurocognitive Efects of Childhood CancerTreatmentJennifer CostaAbstractBackgroundIdentified Risk FactorsTreatment of Childhood Leukemia: Past and PresentTreatment of Childhood Brain Tumors: Past and PresentNeurocognitive Effects of ChemotherapyCognitive RemediationPharmacological Intervention: MethylphenidateConclusion7. The Economic BurdenAlbert I. WertheimerAbstractEpidemiology of Chemo FogDisease ImpactEconomic Burden of Chemo FogConclusion8. Designing Conceptual Model?Based Research in Chemotherapy?Related Changes in Cognitive FunctionLisa M. HessAbstract Understanding the IssueDesigning Research TrialsConclusion9. Neuropsychologic Testing for Chemotherapy?Related Cognitive ImpairmentJamie S. MyersAbstractIntroductionNeuropsychologic Test OverviewIssues Related to Neurocognitive Testing for CRCIConclusion10. Imaging as a Means of Studying Chemotherapy?Related Cognitive ImpairmentRobert B. RaffaAbstractIntroductionElectrophysiological StudiesNeuroimaging StudiesConclusion11. Chemotherapy Associated Central Nervous System DamageJörg DietrichAbstractIntroductionStem Cells, Progenitor Cells and Lineage Systems within the CentralNervousSystemCell?Biological Analysis of Chemotherapy Associated Brain DamageConclusion12. Is Systemic Anti?Cancer Therapy Neurotoxic? Does Chemo Brain Exist? And Should We Rename It?Sophie TaillibertAbstractIntroductionTowards a Better Definition of Chemo BrainTowards a Better Understanding of Chemo BrainDoes Chemo Brain Exist?Conclusion13. Evaluation of Multiple Neurotoxic Outcomes in Cancer ChemotherapyBernard WeissAbstractIntroductionTwo Contrasting Views of NeurotoxicityDimensions of NeurotoxicityLessons Learned from Studies of Cognitive DysfunctionCognitive Function ApproachesSensory FunctionMotor FunctionAnimal ModelsAlternative ApproachesConclusion14. Chemotherapy?Related Visual System ToxicityRobert B. RaffaAbstractIntroductionVisual?System Deficits in Chemo Fog/'Chemo Brain'Chemotherapeutic Agent Toxicity on the Visual SystemConclusion15. The Possible Role of Cytokines in Chemotherapy?Induced Cognitive DeficitsJamie S. MyersAbstractThe Role of Proinflammatory CytokinesOverview of CytokinesThe Immune ResponseProinflammatory Cytokines and CancerProinflammatory Cytokines and Antineoplastic AgentsProinflammatory Cytokines and Sickness BehaviorProinflammatory Cytokines and Other SymptomsFuture ImplicationsConclusion16. Pharmacokinetics of Anti?Cancer Drugs Used in Breast Cancer ChemotherapySwati NagarAbstractIntroductionPharmacokinetics of Anticancer Drugs Used in Breast Cancer ChemotherapyPharmacokinetics in Special Populations: Age and Menopause StatusPharmacokinetics of Anticancer Drugs and Memory Deficit as a Pharmacodynamic EndpointConclusion17. Combination AnalysisRonald J. TallaridaAbstractIntroductionDrug AdditivityTests of Drug Combinations and the IsoboleError EstimatesDose?Effect Relation of the Drug CombinationVariable Potency RatioConclusion18. Animal ModelsEllen A. WalkerAbstractIntroductionEffects of Cancer Chemotherapeutic Agents on the Disruption of SensoryProcessing