Chemo Fog: Cancer Chemotherapy-Related Cognitive Impairment by Robert B. RaffaChemo Fog: Cancer Chemotherapy-Related Cognitive Impairment by Robert B. Raffa

Chemo Fog: Cancer Chemotherapy-Related Cognitive Impairment

EditorRobert B. Raffa, Ronald J. Tallarida

Hardcover | June 10, 2010

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The editors of this book are professors who are engaged in research on areas that compromise the total healing of body and mind in this patient population. One particular component of the need for survivor care is the memory problems and cognitive deficits experienced by some. The condition has been given a name--actually many names, such as chemo fog, chemo brain, and others. These names reflect the belief that the cause of the problem is the chemotherapy that they received as part of their treatment. In some cases the chemo fog/'chemo brain' is transient while in others it is of longer duration. Little is known about this problem and that fact peaked our interest and motivated this book. Therefore this book is devoted to one aspect of survivor care: chemo fog/'chemo brain'.
ROBERT B. RAFFA, PhD, is Professor of Pharmacology and Chair of the Department of Pharmaceutical Sciences at Temple University School of Pharmacy in Philadelphia, Pennslyvania. He holds B Chem E and BS degrees in Chemical Engineering and Physiological Psychology, MS degrees in Biomedical Engineering and Toxicology, and a PhD in Pharmac...
Title:Chemo Fog: Cancer Chemotherapy-Related Cognitive ImpairmentFormat:HardcoverDimensions:232 pagesPublished:June 10, 2010Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441963057

ISBN - 13:9781441963055

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Table of Contents

1. Short Introduction and HistoryRobert B. RaffaAbstractIntroduction and HistoryConclusion2. Patient's PerspectiveRobert B. Raffa and Kathy MartinAbstractIntroductionConclusion3. Oncology Nurse's PerspectiveJamie S. MyersAbstractPrelude: Personal Reflections of an Oncology NurseChemotherapy-Related Cognitive Impairment: The Oncology Nurse PerspectiveOncology Nursing ResearchOncology Nursing EducationConclusion4. Oncology Pharmacist's PerspectiveRachel Clark-VetriAbstractIntroductionConclusion5. The Impact of Chemo Brain on the Patient with a High Grade GliomaMichele R. LucasAbstractBackgroundBrain CancerImpact of Chemo Brain on the PatientImpact of Chemo Brain on the FamilyImpact of Chemo Brain on SocietyConclusion6. Neurocognitive Efects of Childhood CancerTreatmentJennifer CostaAbstractBackgroundIdentified Risk FactorsTreatment of Childhood Leukemia: Past and PresentTreatment of Childhood Brain Tumors: Past and PresentNeurocognitive Effects of ChemotherapyCognitive RemediationPharmacological Intervention: MethylphenidateConclusion7. The Economic BurdenAlbert I. WertheimerAbstractEpidemiology of Chemo FogDisease ImpactEconomic Burden of Chemo FogConclusion8. Designing Conceptual Model-Based Research in Chemotherapy-Related Changes in Cognitive FunctionLisa M. HessAbstract Understanding the IssueDesigning Research TrialsConclusion9. Neuropsychologic Testing for Chemotherapy-Related Cognitive ImpairmentJamie S. MyersAbstractIntroductionNeuropsychologic Test OverviewIssues Related to Neurocognitive Testing for CRCIConclusion10. Imaging as a Means of Studying Chemotherapy-Related Cognitive ImpairmentRobert B. RaffaAbstractIntroductionElectrophysiological StudiesNeuroimaging StudiesConclusion11. Chemotherapy Associated Central Nervous System DamageJörg DietrichAbstractIntroductionStem Cells, Progenitor Cells and Lineage Systems within the CentralNervous SystemCell-Biological Analysis of Chemotherapy Associated Brain DamageConclusion12. Is Systemic Anti-Cancer Therapy Neurotoxic? Does Chemo Brain Exist? And Should We Rename It?Sophie TaillibertAbstractIntroductionTowards a Better Definition of Chemo BrainTowards a Better Understanding of Chemo BrainDoes Chemo Brain Exist?Conclusion13. Evaluation of Multiple Neurotoxic Outcomes in Cancer ChemotherapyBernard WeissAbstractIntroductionTwo Contrasting Views of NeurotoxicityDimensions of NeurotoxicityLessons Learned from Studies of Cognitive DysfunctionCognitive Function ApproachesSensory FunctionMotor FunctionAnimal ModelsAlternative ApproachesConclusion14. Chemotherapy-Related Visual System ToxicityRobert B. RaffaAbstractIntroductionVisual-System Deficits in Chemo Fog/'Chemo Brain'Chemotherapeutic Agent Toxicity on the Visual SystemConclusion15. The Possible Role of Cytokines in Chemotherapy-Induced Cognitive DeficitsJamie S. MyersAbstractThe Role of Proinflammatory CytokinesOverview of CytokinesThe Immune ResponseProinflammatory Cytokines and CancerProinflammatory Cytokines and Antineoplastic AgentsProinflammatory Cytokines and Sickness BehaviorProinflammatory Cytokines and Other SymptomsFuture ImplicationsConclusion16. Pharmacokinetics of Anti-Cancer Drugs Used in Breast Cancer ChemotherapySwati NagarAbstractIntroductionPharmacokinetics of Anticancer Drugs Used in Breast Cancer ChemotherapyPharmacokinetics in Special Populations: Age and Menopause StatusPharmacokinetics of Anticancer Drugs and Memory Deficit as a Pharmacodynamic EndpointConclusion17. Combination AnalysisRonald J. TallaridaAbstractIntroductionDrug AdditivityTests of Drug Combinations and the IsoboleError EstimatesDose-Effect Relation of the Drug CombinationVariable Potency RatioConclusion18. Animal ModelsEllen A. WalkerAbstractIntroductionEffects of Cancer Chemotherapeutic Agents on the Disruption of SensoryProcessing in Animal ModelsEffects of Cancer Chemotherapeutic Agents on the Disruption of Motorand Spontaneous Behavior in Animal ModelsEffects of Cancer Chemotherapeutic Agents on Motivational Behavior in Animal ModelsAcute Effects of Cancer Chemotherapeutic Agents on Learning and Memoryin Animal ModelsRepeated Treatment of Cancer Chemotherapeutics in Animal ModelsPotential Neural Mechanisms of Chemotherapy-Induced Learning and Memory ImpairmentsConclusion19. Chemo Brain (Chemo Fog) as a Potential Side Efect of Doxorubicin Administration: Role of Cytokine-Induced, Oxidativ e/Nitrosativ e Str ess in Cognitive DysfunctionChristopher D. Aluise, Rukhsana Sultana, Jitbangjong Tangpong, Mary Vore,Daret St. Clair, Jeffrey A. Moscow and D. Allan ButterfieldAbstractIntroductionDescription of DOX and Mechanisms of ActionToxicity of DOXDescription of Chemo Fog in Context of DOXConclusion 20. Efects of 5-FUPeter M. Wigmore, Sarah Mustafa, Maha El-Beltagy, Laura Lyons,Jariya Umka and Geoff BennettAbstractIntroductionAnimal ModelsConclusion21. Future DirectionsRobert B. Raffa and Ronald J. TallaridaAbstractBackgroundChemo Fog/Chemo Brain: CurrentChemo Fog/Chemo Brain: FutureConclusionSuggested ReadingIndex