Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management by Guy B. FaguetChronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management by Guy B. Faguet

Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management

EditorGuy B. Faguet

Paperback | November 9, 2010

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A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL. The authors focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogenic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.
Title:Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and ManagementFormat:PaperbackDimensions:435 pages, 10 × 7.01 × 0.01 inPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617373559

ISBN - 13:9781617373558

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Table of Contents

Part I. IntroductionThe Natural History of CLL: Historical PerspectiveGerald E. Marti and Vincent ZengerPart II. Biology and GeneticsGenetics of B-Cell Chronic Lymphocytic LeukemiaStephan Stilgenbauer, Peter Lichter, and Hartmut DöhnerMolecular Biology of Chronic Lymphocytic LeukemiaWilliam G. WierdaThe Heterogeneous Origin of the B-CLL CellTerry HamblinPathogenesis of Impaired Cellular Immune Function in CLLPatrick B. Johnston and Neil E. KayCytokines and Soluble Molecules in CLLEnrica Orsini and Robin FoaPart III. Clinical Aspects: DiagnosisImmunophenotypic Differential Diagnosis and Cell Cycle AnalysisVonda K. Douglas and Raul C. BraylanCommon Cytogenetic AbnormalitiesGunnar JuliussonImmunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic LeukemiaAlberto Orfao, Julia Almeida, Maria Luz Sanchez, and Jesus F. San MiguelPart IV. Clinical Aspects: PrognosisStaging of Chronic Lymphocytic Leukemia, Kanti R. Rai and Niraj Gupta. Prognostic Indicators of Chronic Lymphocytic Leukemia, Francesc Bosch and Emili MontserratPart V. Clinical Aspects: TreatmentGuidelines for Clinical Management of CLLGuillaume DighieroChemotherapy of Chronic Lymphocytic LeukemiaAlessandra Ferrajoli, Michael J. Keating, and Susan M. O'BrienAutologous and Allogeneic Transplantations for Chronic Lymphocytic LeukemiaMauricette MichalletMonoclonal Antibody Therapy in Chronic Lymphocytic LeukemiaThomas S. Lin, Margaret S. Lucas, and John C. ByrdImmunotoxin Therapy of Chronic Lymphocytic LeukemiaArthur E. Frankel and Robert J. KreitmanNew Treatment Strategies in Chronic Lymphocytic LeukemiaUpendra P. Hegde and Wyndham H. WilsonGene Therapy of Chronic Lymphocytic LeukemiaJanuario E. Castro and Thomas J. KippsPart VI. Clinical Aspects: ComplicationsInfections in Patients With Chronic Lymphocytic LeukemiaGerald P. Bodey, Dimitrios Kontoyiannis, and Michael J. KeatingAutoimmune and Hypersplenic CytopeniasTerry HamblinClonal Evolution and Second Malignancies in B-CLLGuy B. FaguetPart VII. Familial and Juvenile Chronic Lymphocytic LeukemiaInherited Predisposition to Chronic Lymphocytic LeukemiaMartin R. Yuille, Daniel Catovsky, and Richard S. HoulstonYoung Patients With Chronic Lymphocytic LeukemiaFrancesca R. Mauro and Robin FoaIndex

Editorial Reviews

"This book will certainly be a very useful reference work for the practicing adult haematologist." - Pediatric Hematology Oncology