Cleft Lip and Palate: From Origin to Treatment

Hardcover | August 15, 2002

EditorDiego F. Wyszynski

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Majoradvances in the diagnosis and treatment of oral clefts have been made in the past 50 years, and recent genetics and epidemiological studies have led to new theories about the causes of cleft lip and palate. Addressing issues that are relevant to clinicians, researchers and familymembers, this book is a comprehensive, well-illustrated, and up-to-date account of the many facets of this common disorder. The authors describe the embryological and molecular mechanisms of cleft causation, present and illustrate the genetic and epidemiological methods used to identify riskfactors for oral clefts, and describe treatments by the various professionals of the cleft team. A section is also devoted to the integration of research findings into public health practice, including ethical and financial considerations. The book draws together such diverse disciplines ascraniofacial development, gene mapping, epidemiology, medicine, ethics, health economics, and health policy and management, and it will be an invaluable reference work.

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Majoradvances in the diagnosis and treatment of oral clefts have been made in the past 50 years, and recent genetics and epidemiological studies have led to new theories about the causes of cleft lip and palate. Addressing issues that are relevant to clinicians, researchers and familymembers, this book is a comprehensive, well-illustr...

Diego F. Wyszynski is at National Institute of Dental and Craniofacial Research.

other books by Diego F. Wyszynski

Format:HardcoverDimensions:548 pages, 8.58 × 11.18 × 1.69 inPublished:August 15, 2002Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195139062

ISBN - 13:9780195139068

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Table of Contents

ForewordSection I Basic PrinciplesPart I Basic Embrology of Cleft Lip and Palate1. Geoffrey H. Sperber, University of Alberta: Formation of the Primary Palate2. Geoffrey H. Sperber, University of Alberta: Palatogenesis: Closure of the Secondary Palate3. Samuel S. Chong, Felicia S.H. Cheah, and Ethylin Wang Jabs SC, FC: National University of Singapore; EJ: John Hopkins University: Genes Implicated in Lip and Palate DevelopmentPart II Clinical Features of Cleft Lip and Cleft Palate4. Eric A. Wulfsberg, University of Maryland: The Orofacial Exampination: Normal and Abnormal Findings5. Howard M. Saal, University of Cincinnati: Classification and Description of Nonsyndromic Clefts6. M. Michael Cohen, Jr., Dalhousie University: Syndromes with Orofacial Clefting7. Richard E. Ward, Elizabeth S. Moore, and James K. Hartsfield, Jr., RW: Indiana University and Purdue University; EM, JH: Indiana University School of Dentistry: Morphometric Characteristics of Subjects with Oral Facial Clefts and Their Relatives8. Sven Kreiborg and Nuno V. Hermann, University of Copenhagen (both): Craniofacial Morphology and Growth in Infants and Young Children with Cleft Lip and PalatePart III Epidemiology of Cleft Lip and Palate9. Kaare Christensen, university of Southern Denmark (Odense): Methodological Issues in Epidemiological Studies of Oral Clefts10. Martha M Werler, Boston University School of Public Health: Exposure Assessment in Studies of Oral Clefts11. Adolfo Correa and Larry Edmonds, Centers for Disease Control and Prevention (both): Birth Defects Surveillance Systems and Oral Clefts12. Epidemiology of Oral Clefts: An International Perspective, Peter A. Mossey and Julian Little, PM: Dundee Dental School; JL: University of Aberdeen13. Catherine Hayes, Harvard School of Dental Medicine: Environmental Risk Factors and Oral Clefts14. Ronald G. Munger, Utah State University: Maternal Nutrition and Oral Clefts15. Barbara D. Abbott, Environmental Protection Agency: Experimental Models for the Study of Oral CleftsPart IV Genetics of Cleft Lip and Palate16. Janee Gelineau-van Waes and Richard H. Finnell, JG: Nebraska Medical Center; RF: Texas A and M University: The Human Genome Project17. Laura E. Mitchell, University of Pennsylvania: The Role of Twin Studies in Oral Clefts Research18. Mary L. Marazita, University of Pittsburgh Schools of Dental Medicine and Public Health: Segregation Analyses19. Laura E. Mitchell, University of Pennsylvania: Mode of Inheritance of Oral Clefts20. Mary L. Marazita and Katherine Neiswanger, MM: see #18, KN: University of Pittsburgh School of Dental Medicine: Associate Studies21. Diego F. Wyszynski, Boston University Schools of Medicine and Public Health: Locating Genes for Oral Clefts in Humans22. Diana M. Juriloff, University of British Columbia: Mapping Studies in Animal Models23. Joanna S. Zieger and Terri H. Beaty, John Hopkins University Bloomberg School of Public Health (both): Gene-Environment Interaction and Risk to Oral CleftsSection II Treatment24. Ronald P. Strauss, University of North Carolina: Developing a Cleft Palate or Craniofacial Team25. John A. Nackashi, E. Rosellen Dedlow, and Virginia Dixon Wood, University of Florida (all): Health Care for Children with Cleft Lip and Palate: Comprehensive Services and Infant Feeding26. Jeffrey C. Posnick and Ramon L. Ruiz, JP: Georgetown University; RR: University of North Carolina: The Staging of Cleft Lip and Palate Reconstruction: Infancy through Adolescence27. John E. Riski, Children's Healthcare of Atlanta: Evaluation and Management of Speech, Language, and Articulation Disorders28. Frank Farrington, Virginia Commonwealth University School of Dentistry: Pediatric Dental Care29. Andrew C. Lidral and Katherine W.L. Vig, AL: University of Iowa; KV: The Ohio State University: The Role of the Orthodontist in the Management of Patients with Cleft Lip and/or Palate30. Patrick J. Antonelli, University of Florida: Otolaryngologic Needs of Individuals with Oral Clefts31. Carmella S. Stadter, University of Maryland: Genetic Counseling and Interpretation of Risk Figures32. Kathleen A. Kapp-Simon, Northwestern University Cleft Lip and Palate Institute: The Psychological Care of Children with Cleft Lip and Palate in the Family33. S.T. Lee, Singapore General Hospital: International Surgical Missions34. William C. Shaw and Gunvor Semb, WS: University Dental Hospital of Manchester (both): Evidence-Based Care for Children with Cleft Lip and PalateSection III Public Health Issues35. Andrew E. Czeizel, Foundation for the Community Control of Hereditary Diseases(Budapest, Hungary): Prevention of Oral Clefts Through the Use of Folic Acid and Multivitamin Supplements: Evidence and Gaps36. Nancy W. Berk and Mary L. Marazita, NB: University of Pittsburgh School of Dental Medicine, MM: see #18: The Costs of Cleft Lip and Palat: Personal and Societal Implications37. David A. Billmire, Children's Hospital Medical Center (Cincinnati, Ohio): Insurance and Coverage of Care38. Jane Nicholson, University of Michigan: Parent's Perspective on Cleft Lip and Palate39. Ronald P. Strauss, University of North Carolina: Ethical Issues in the Care of Children with Craniofacial Conditions40. Richard S. Onley, Emory University: Translating Research Findings into Public Health Action and Policy41. Marilyn C. Jones, University of California, San Diego: Educating the Practitioner and the Public42. Negato Ntsume, David S. Precious, and Hermann F. Sailer NN: Aichi-Gakuin University, Japan; DP: Dalhousie University; HS: University Hospital(Zurich, Switzerland): Innovative Attempts Toward International CooperationAppendix: Internet Resources

Editorial Reviews

"Diego Wyszynski has done an admirable job of assembling a collection of reviews of various aspects of the etiology and treatment of oral clefts. Of particular value to clinicians and well-informed family members is the section on treatment. The treatment of patients with oral clefts, frombirth to adulthood, requires a well-coordinated team effort. This section does a good job of conveying the global nature and specific details of this comprehensive care."--Am. J. Hum. Genetics