Clinical and Translational Science: Principles of Human Research

Other | March 2, 2009

byDavid Robertson, David Robertson, Gordon H. Williams

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Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health.

This book is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science.

* Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications

* Contributions from international leaders provide insight into background and future understanding for clinical and translational science

* Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

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From the Publisher

Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead ...

Dr. Williams' group's first major goal is the identification of the genetic underpinnings of endocrine factors related to cardiovascular (CV) risk in hypertension and diabetes with the ultimate goal of using genetic markers to develop individualized, personal treatment programs for patients with these diseases. His is a translational r...

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Format:OtherDimensions:600 pages, 1 × 1 × 1 inPublished:March 2, 2009Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080920195

ISBN - 13:9780080920191

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Extra Content

Table of Contents

List of Contributors

Foreword

Acknowledgments

Introduction to Clinical Research

Part I Fundamental Principles

1 Patient-Oriented Research: Clinical Pathophysiology and Clinical Therapeutics

2 Clinical Trials

Part II Approaches

3 Experimental Design

4 Introduction to Biostatistics Ideas

5 Measurement of Biological Materials

6 Imaging Tools in Human Research

7 Imaging Tools in Cardiovascular Research

8 Nanotechnology in Clinical and Translational Research

9 The Use of Questionnaires and Surveys

10 Information Technology

Part III Infrastructure

11 Clinical and Translational Science Infrastructure

12 Industry-Sponsored Clinical Research in Academia

Part IV Education, Training and Career Choices

13 Training Basic, Clinical and Translational Investigators

14 A Stepwise Approach to a Career in Translational Research

15 Physician Careers in Industry

Part V Funding

16 Governmental Support of Research

17 Support of Health Research by Private Philanthropy

18 Pharmaceutical and Biotechnology Sector Support of Research

Part VI Human Genetics

19 Introduction to Human Genetics

20 Epidemiologic and Population Genetic Studies

21 Pharmacogenetics of Drug Metabolism

Part VII Human Pharmacology

22 Introduction to Clinical Pharmacology

23 Toxicology and Genetics of Adverse Drug Events

24 Good Clinical Practice and Good Laboratory Practice

25 Modern Drug Discovery and Development

Part VIII Societal Context of Human Research

26 Translating Science to the Bedside: The Innovation Pipeline

27 Regulatory Environment

28 Ethical Issues in Translational Research and Clinical Investigation

29 Clinical Research in the Public Eye

Part IX Research in Special Populations

30 Acute Illnesses, Critical Care, Emergency and Surgical Patients

31 Psychiatric Disorders

32 Geriatrics

33 Pediatrics

Part X Population-Based Research

34 Pharmacoeconomics: The Economic Evaluation of New Medical Technology

35 Introduction to Epidemiology

36 Health Services Research: Translating Discovery and Research into Practice and Policy

Part XI Prospectus

37 The Future of Clinical Research

Index