The Clinical Manual for the Treatment of Schizophrenia provides a wide-ranging, empirically based review of assessment and treatment issues in schizophrenia, offered from a multicultural and supremely patient-centered perspective. The following features reflect the care taken in developing this manual, as well as the inclusive nature of the contents: The initial chapter offers a thorough introduction to the disease -- its history, etiology, epidemiology, risk factors, and social aspects -- seen through the lens of a case study. The chapter ends with an overview of the diagnostic process, allowing the reader to place what follows into context. The basic science underlying schizophrenia is explained next, with coverage of biological markers; brain structure, function, and cytology; the dopamine and glutamate hypotheses; and the neurodevelopmental model of the disease. The chapter on clinical assessment focuses on making the differential diagnosis according to established criteria, with emphasis on a person-oriented approach that takes into account early trauma, stressful events, and the subjective well-being of the patient. Subsequent chapters explore cognition, comorbidity, substance abuse, and treatment-resistant symptoms in schizophrenia. Finally, chapters on the pharmacological and psychosocial treatment of schizophrenia compare and contrast these approaches, ensuring that the reader is completely up-to-date and knowledgeable about available treatment options. Clinicians who work with schizophrenic patients in a variety of settings -- from private practice to emergency departments -- will benefit from the scholarship and experience of this manual's astute and insightful authors.