Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals

Hardcover | October 6, 2008

OtherWilliam M. BennettEditorMarc E. De Broe, George A. Porter

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Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals, Third Edition is a comprehensive text on all aspects of adverse effects by drugs, chemical substances and radiation on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized. The book consists of themes such as clinical relevance, renal handling and cellular mechanisms of nephrotoxicity, as well as animal and cell culture models. In addition, the volume highlights specific types of drugs, such as anti-infectious agents and anti-inflammatory, cardiovascular and anti-cancer drugs. The last section deals with prevention and focuses on urinary biomarkers, pharmacological aspects and drug dosage in renal failure. In this third and completely revised edition, several new topics were added and additional figures and tables will be included.The book is of interest for the nephrologist, internist, general practitioner, toxicologist, pharmacologist, anesthesiologist, epidemiologist, public health official, pharmaceutical industry, and national drug safety committees, among others.

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From the Publisher

Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals, Third Edition is a comprehensive text on all aspects of adverse effects by drugs, chemical substances and radiation on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized. The book consists of themes such as cl...

From the Jacket

Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals is a comprehensive handbook on all aspects of adverse effects by drugs and chemical substances on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized.The first, general part deals with themes as clinical relevan...

Format:HardcoverDimensions:1008 pages, 10.98 × 8.27 × 0.03 inPublished:October 6, 2008Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387848428

ISBN - 13:9780387848426

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Table of Contents

From the contentsClinical Relevance/Approach.- Drug Associated Acute Renal Failure in the Intensive Care Unit.- Renal Handling of Drug and Xenobiotics.- Pharmacovigilance.- Immunologically-Mediated Toxin-Induced Renal Disease.- Cellular Mechanisms of Nephrotoxicity.- Animal Models for the Assessment of Acute Renal Dysfunction and Injury.- Renal Cell Culture Models: Contribution to the Understanding of Nephrotoxic Mechanisms.- Aminoglycosides and Vancomycin.- Beta-Lactam Antibiotics.- Amphotericin B.- Sulfonamides, Sulfadiazine, Timethoprim-Sulfamethoxazole, Pentamidine, Pyrimethamine, Dapsone, Quinolones.- Antiviral Agents.- Analgesics and 5-Aminosalicylic Acid.- Non-Steroidal Anti-Inflammatory Drugs.- Gold Salts, D-Penicillamine and Allopurinal.- Angiotensin I Converting Enzyme Inhibitors and Angiotensin II Receptor Antagonists.- Diuretics.- Anticancer Drugs.- Anesthetic Agents.- Proton Pump Inhibitor-Associated Acute and Chronic Interstitial Nephritis.- Illicit Drug Abuse.

Editorial Reviews

From the reviews of the third edition:"The purpose is to provide a guide with balanced and agreed-upon information about renal injury from drugs and chemicals. . This book is a useful source of information for general clinicians, and nephrologists in particular. Intensivists, pharmacists, and investigators will also find it quite helpful. . The book is well written, easy to read, and covers essential topics in a logical sequence. . This book is particularly useful for nephrologists and I highly recommend it to medical and hospital libraries." (Aziz Chami, Doody's Review Services, February, 2009)