Clusterin, Part B

Other | October 26, 2009

bySaverio Bettuzzi, Saverio Bettuzzi, Sabina Pucci

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The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.

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The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass ...

Format:OtherDimensions:350 pages, 1 × 1 × 1 inPublished:October 26, 2009Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123814308

ISBN - 13:9780123814302

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Table of Contents

1. CLU and prostate cancer.

S. Bettuzzi and F. Rizzi

2. The role of Clusterin (CLU) in malignant transformation and drug resistance in breast carcinomas

Maximino Redondo; Teresa Tellez; María Jose Roldan.

3. CLU and COLON CANCER

The dual face of CLU: from normal to malignant phenotype

Mazzarelli P. Pucci S. Spagnoli L.G.

4. Clusterin (CLU) and lung cancer

F. Panico*,2F. Rizzi*,1L.M. Fabbri, and2S. Bettuzzi°,1F. Luppi°

5. CLUSTERIN AND CHEMORESISTANCE

Julie Y. Djeu and Sheng Wei

6. CLU "in and out": looking for a link

Pucci S.1, Mazzarelli P.1, Nucci C.2, Ricci F.2, Spagnoli L.G.1

7. Regulation of CLU gene expression by oncogenes and epigenetic factors: Implications for tumorigenesis

Arturo Sala,2 *Saverio Bettuzzi,3Sabina Pucci,1Olesya Chayka,4Michael Dews, and4Andrei Thomas-Tikhonenko

8. CONCLUSIONS AND PERSPECTIVES

Saverio Bettuzzi