Co-Existence and Co-Release of Classical Neurotransmitters: Ex uno plures

Hardcover | December 4, 2008

EditorRafael Gutierrez

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Dale's Principle postulated that a neuron functions as a metabolic unit, whereby a process occurring in the cell can influence all of the compartments of that given neuron. This was unfortunately transformed in the literature to a principle stating that "a single cell releases only one neurotransmitter". Until recently, this has influenced many neuroscientists to consider with skepticism the idea that classical neurotransmitters could be co-released from neurons.It is now clear that the "one neuron, one neurotransmitter" postulate is the exception rather than the rule. The aim of this book is to gather the available evidence, provided by the authors that have discovered and studied the co-existence or co-release of several pairs of neurotransmitters, in several neural networks. It will provide a timely overview of a mechanism of neural communication that is likely to attract increasing attention of the neuroscientific community.

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Dale's Principle postulated that a neuron functions as a metabolic unit, whereby a process occurring in the cell can influence all of the compartments of that given neuron. This was unfortunately transformed in the literature to a principle stating that "a single cell releases only one neurotransmitter". Until recently, this has influe...

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Until recently, many neuroscientists were skeptical of the idea that classical neurotransmitters could be co-released from neurons. It is now common knowledge, though, that the "one neuron, one neurotransmitter" postulate is the exception rather than the rule. Co-Existence and Co-Release of Classical Neurotransmitters provides readers ...

Format:HardcoverDimensions:256 pages, 9.25 × 6.1 × 0.27 inPublished:December 4, 2008Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387096213

ISBN - 13:9780387096216

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Table of Contents

Mechanisms of synapse formation: Activity-dependent selection of neurotransmitters and receptors.- Regulation of cardiac excitation and inhibition through modulation of sympathetic co-transmission.- The dual glutamatergic/GABAergic phenotype of the hippocampal granule cells.- Glycine-GABA-glutamate co-transmission at developing central auditory synapses.- GABA actions at an excitatory synapse in the hippocampus.- Glutamate co-release by monoamine neurons.- Postsynaptic determinants of inhibitory transmission at mixed GABAergic/glycinergic synapses.- GABA is the main neurotransmitter released from mossy fiber terminals in the developing hippocampus.- The corelease of glutamate and acetylcholine in vertebrate central nervous system.- Co-release of GABA and ATP.- Interactions within Catecholamine Systems: co-release of dopamine and serotonin.- Colocalization and Cotransmission of Classical Neurotransmitters: An Invertebrate Perspective.- Out of many, one: Integration of co-released neurotransmitters.