Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds

Other | July 1, 1994

byAugust, J. Thomas, J. Thomas August

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Each volume ofAdvances in Pharmacologyprovides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.
This special volume ofAdvances in Pharmacologyfeatures a two-color dust jacket.

Key Features
* Summarizes the most recent information on:
* Xenobiotic conjugation
* Drug toxicity, hypersensitivity, and targeting
Chemical carcinogenesis
* Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity
* Bioactivation and bioconversion

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Each volume ofAdvances in Pharmacologyprovides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mec...

Format:OtherDimensions:519 pages, 1 × 1 × 1 inPublished:July 1, 1994Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080581188

ISBN - 13:9780080581187

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Table of Contents

J.A. Miller and Y.-J. Surh, Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds.
Glutathione-Dependent Toxicity:
C. Andersson, E. Mosialou, R. Weinander, and R. Morgenstern, Enzymology of Microsomal GlutathioneS-Transferase.
B. Ketterer and L.G. Christodoulides, Enzymology of Cytosolic GlutathioneS-Transferases.
A.J.L. Cooper, Enzymology of CysteineS-Conjugate b-Lyases.
W. Dekant, S. Vamvakas,and M.W. Anders, Formation and Fate of Nephrotoxic and Cytotoxic GlutathioneS-Conjugates: Cysteine Conjugate b-Lyase Pathway.
T.A. Baille and K. Kassahun, Reversibility in Glutathione-Conjugate Formation.
T.J. Monks and S.S. Lau, Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites.
F.P. Guengerich, Metabolism and Genotoxicity of Dihaloalkanes.
R. Munday, Bioactivation of Thiols by One-Electron Oxidation.
N. Ballatori, Glutathione Mercaptides as Transport Forms of Metals.
Sulfate Conjugate-Dependent Toxicity:
C.N. Falany and T.W. Wilborn, Biochemistry of Cytosolic Sulfotransferases Involved in Bioactivation.
C.J. Michejda and M.B.K. Koepke, Carcinogen Activation by Sulfate Conjugate Formation.
Glucuronide Conjugate-Dependent Toxicity:
K.W. BockUDP-Glucuronsyltransferases and Their Role in Metabolism and Disposition of Carcinogens.
P. Zia-Amirhosseini, H. Spahn-Langguth, and L.Z. Benet, Bioactivation of Glucuronide-Conjugate Formation.Bioactivation and Bioconversion:
P.E. Hanna,N-Acetyltransferases,O-Acetyltransferases, andN,O-Acetyltransferases: Enzymology and Bioactivation.
M.W. Anders and W. Dekant, Aminoacylases.
J.L. Hoffman, Bioactivation by S-Adenosylation, S-Methylation, or N-Methylation.
S. Vamvakas and M.W. Anders, Bioconversion of Prodrugs by Conjugate-Processing Enzymes.
Subject Index.