Cortical Oscillations in Health and Disease

Hardcover | May 26, 2010

byRoger D. Traub, Miles A. Whittington

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This book first reviews the case that brain oscillations not only are important for cognition, as long suspected, but also play a part in the expression of signs and symptoms of neuropsychiatric disorders. The cellular mechanisms of many of the clinically relevant oscillations have beenstudied by the authors and their colleagues, using in vitro slice methods as well as detailed computer simulations. A surprising insight is that gap junctions between principal neurons play an absolutely critical role in so many types of oscillation in neuronal populations; oscillations are notjust the result of properties of individual neurons and their synaptic connections. Furthermore, the way in which gap junctions produce oscillations in the cortex is novel, involving as it does global properties of networks, rather than just the time constants of membrane currents. This insighthas implications for therapeutics as well as for our understanding of normal brain functions.

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This book first reviews the case that brain oscillations not only are important for cognition, as long suspected, but also play a part in the expression of signs and symptoms of neuropsychiatric disorders. The cellular mechanisms of many of the clinically relevant oscillations have beenstudied by the authors and their colleagues, usin...

Dr. Traub was educated in mathematics at Princeton, and medicine and neurology at U Penn and Columbia, respectively. He is a founder of the field of detailed modeling of neuronal networks, and has applied this type of modeling to the study of brain oscillations and epilepsy, collaborating closely with Dr. Whittington since the early ...

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Format:HardcoverDimensions:464 pages, 9.25 × 6.13 × 0.98 inPublished:May 26, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195342798

ISBN - 13:9780195342796

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Table of Contents

AbbreviationsSection I. Overview of normal and abnormalcortical oscillations1. Introduction2. Historical Prelude3. Overview of in vivo cortical oscillations4. Epilepsy5. Parkinson's Disease6. Schizophrenia7. Cerebellar AtaxiaSection II. Basic properties of single neurons and gap junctions8. Single Neurons9. Basic properties of gap junctionsSection III. Some in vitro oscillations10. Very fast ocsillations (VFO)11. Gap junction-dependent cortical beta2 oscillations (20 - 30 Hz)12. Gap junction-dependent persistent gamma oscillaitons (30 - 70 Hz)13. Epileptiform discharges in vitroSection IV. Implications for Health and Disease14. ConclusionIndex