COX-2 Blockade in Cancer Prevention and Therapy by Randall E. HarrisCOX-2 Blockade in Cancer Prevention and Therapy by Randall E. Harris

COX-2 Blockade in Cancer Prevention and Therapy

EditorRandall E. Harris

Paperback | November 19, 2010

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This book chronicles the evidence for the chemopreventive and therapeutic effects of cyclooxygenase-2 (COX-2) inhibitors against virtually all forms of cancer and presents exciting new opportunities for the use of COX-2 blockade in its prevention and treatment. The authors elucidate the process by which COX-2 inhibitors interrupt prostaglandin biosynthesis and cancer development, examine the positive epidemiological effects of such NSAIDs as aspirin and ibuprofen on various cancers, and demonstrate through animal models that COX-2 inhibitors and NSAIDs inhibit a variety of malignant neoplasms in vivo. They also present genetic models confirming the critical role of COX-2 in carcinogenesis and discuss how its molecular biology modulates carcinogenesis. In addition, the authors review the clinical applications of selected NSAIDs that are immediately relevant to cancer prevention and control and outline the future prospects of COX-2 blocking agents.
Title:COX-2 Blockade in Cancer Prevention and TherapyFormat:PaperbackDimensions:381 pagesPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617373044

ISBN - 13:9781617373046

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Table of Contents

Part I. Historical PerspectivesDietary Fatty Acids, COX-2 Blockade, and CarcinogenesisRashida A. KarmaliHistorical Aspects of COX-2: Cloning and Characterization of the cDNA, Protein and GeneHarvey R. HerschmanPart II. Epidemiology of NSAIDs and CancerEpidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal CancerMichael J. Thun and S. Jane HenleyEpidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast CancerRandall E. HarrisPart III. Animal Models of CarcinogenesisRole of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer PreventionBandaru S. Reddy and Chinthalapally V. RaoChemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in AnimalsHussein M. Abou-Issa, Galal A. Alshafie, and Randall E. HarrisThe Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung CancerHildegard M. SchullerNonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal TumorigenesisJay Whelan and Michael F. McEnteeCyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory DrugsRobert LangenbachPart IV. Molecular Biology of COX-2Cyclooxygenase-2, Prostaglandins, and Colorectal CarcinogenesisRajnish A. Gupta and Raymond N. DuBoisRegulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2Byeong-Churl Jang and Timothy HlaCyclooxygenase-2 and CancerAlane T. Koki, Kathleen M. Leahy, Janet M. Harmon, and Jaime L. MasferrerInteractions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast CellsJeanette A. Richards and Robert W. BrueggemeierAssociation of COX-2 and PPARs in Carcinogenesis and ChemopreventionTong-Chuan HeCarcinogenesis Involving Cyclooxygenase and LipoxygenaseLinda C. Hsi and Thomas E. ElingPart V. Clinical ApplicationsThe Development of Drugs that Target Cyclooxygenase-2Timothy Maziasz, K. Nasir Khan, John Talley, James Gierse, and Karen SeibertChemoprevention of Cancer by NSAIDs and Selective COX-2 BlockadeGary J. Kelloff, Vernon E. Steele, and Caroline C. SigmanPotential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor RadioresponseRandy Burd, Hak Choy, and Adam DickerPotential Role of NSAIDs and COX-2 Blockade in Cancer TherapyWilliam F. Anderson, Asad Umar, Jaye L. Viner, and Ernest T. HawkCyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of ImpactRandall E. HarrisIndex

Editorial Reviews

"...a must, not only for oncologists but also for every family doctor, who is often the first to see a patient with a cancerous or precancerous or precancerous condition." -Lancet Oncology"This comprehensive and up-to-date monograph demonstrates how COX-2 inhibitors and other NSaids reduce the risk of most cancers and provides cancer investigators by a clear and authoritative guide leading to the development of novel angst with significant antineoplastic properties." -Neoplasma