Creatine and Creatine Kinase in Health and Disease

byGajja S. SalomonsEditorMarkus Wyss

Paperback | November 20, 2010

Creatine and Creatine Kinase in Health and Disease by Gajja S. Salomons
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Although creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to oral creatine supplementation, such as neuroprotective, ergogenic, anti-diabetic, anti-inflammatory, antiviral, or antitumor effects. Creatine may even improve memory and intelligence. In the present book, emphasis is placed on the intricate interplay between creatine and creatine kinase function on one hand, and proper brain function, neurodegenerative disease and/or neuroprotection on the other hand. The book also elaborates on the recently identified inborn errors of creatine biosynthesis and transport, the so-called cerebral creatine deficiency syndromes. The clinical hallmarks of these disorders are mental retardation, epilepsy, autistic-like behaviour, and speech and language delay. In addition, the muscle growth- and strength-promoting effects, the pharmacokinetics and the safety of oral creatine supplementation are discussed. Finally, the present book outlines the emerging "systems biology" approaches for understanding the pleiotropic effects of creatine and creatine kinase, and hypothesizes on the most promising and influential future avenues of research towards creatine-based nutritional strategies for the prevention of neurological disease, and for improving the quality of life in general.

Foreword. Gajja S. Salomons and Markus Wyss Introduction - Creatine: cheap ergogenic supplement with great potential for health and disease. Theo Wallimann Early evolution of the creatine kinase gene family and the capacity for creatine biosynthesis and membrane transport. W. Ross Ellington and Tomohiko Suzuki The creatine kinase phosp...
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Title:Creatine and Creatine Kinase in Health and DiseaseFormat:PaperbackProduct dimensions:354 pages, 23.5 X 15.5 X 0 inShipping dimensions:354 pages, 23.5 X 15.5 X 0 inPublished:November 20, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9048176522

ISBN - 13:9789048176526

Appropriate for ages: All ages

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